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NEET 2019:
NTA would activate the link for correction window of NEET 2019 tomorrow - January 14, 2019. Important instructions on changes that can be made,
ntaneet.nic.in

FEED UR BRAIN: HIV REPLOCATION CYCLE
Attachment :
The gp120 attaches to the attachment receptor CD4. This attachment is reversible and important for HIV entry although not mandatory. Gp120 then binds to the entry receptor CXCR4, which is a signalling receptor. LxK kinase bound to the cytoplasmic tail of CD4 may phosphorylate CXCR4. It is unclear if the virus fuses at the cell surface or is endocytosed by the clathrin mechanism.

Virion component release in cell cytoplasm :
After virus-host membrane fusion, viral capsid is released in the cytoplasm. Vpx(HIV-2 only) is presumably transported to the nucleus where it would act to counteract host restriction factor to reverse-transcription/PIC entry.

Reverse transcription :
comment: does diploidy play a role during reverse transcription? Several studies have addressed the question, they all agree that second strand transfer is intramolecular, but the first strand transfer would be: intermolecular intramolecular or a mix of both

Transport :
The viral capsid interacts with microtubules and is actively transported to the vicinity of the cell nucleus. This transport takes 40 min ex vivo.

Uncoating and nuclear entry :
Uncoating is the process whereby the cDNA viral genome gets out of the capsid. It is a multistep process, closely linked to reverse transcription. Early uncoating may occur under certain circumstances and leads to infection abortion: CypA depletion, simian Trim5alpha binding, Mx2 antiviral protein expression or cytoplasmic CPSF6. Early uncoating may induce cytoplasmic dsDNA sensor antiviral response.
The pre-integration complex (cDNA, Integrase) entry into the nucleus occurs through various binding to nuclear pore and is dependent on the presence of vpr.

Integration :
The viral cDNA is covalently integrated into the host genome by the integrase, preferentially at transcription active places. Integrated virus genome is called the provirus.

Latency/ replication decision :
The integrated provirus can get methylated in the host genome, and this transcriptional silencing induces viral latency. Alternatively, the provirus can be transcribed enough to reach a tat expression allowing to enter in replicative phase.

Latency/ reactivation :
Cellular stress or activation can lead to nuclear signals that remove the provirus transcriptional silencing, thereby inducing the viral replication cycle.

Transcription :
Provirus transcription is under the control of tat and many host transcription factors that interacts with U3 promoter. mRNA transcripts are alternatively spliced into six mRNAs.

GRNA nuclear exit :
The unspliced genomic RNA (gRNA) cannot be exported to the cytoplasm under normal circumstance. The rev viral protein specifically unlocks gRNA export into the cytoplasm, which are both templates for GAG and POL translation, and the genetic material susceptible to bud in new virions.

Virion assembly and budding :
The genomic packaging signal (Phi) is present only in gRNA. In the monomeric gRNA, The Phi element is sequestered by intramolecular base pairing and then become exposed upon dimerization, thereby allowing specific, high-affinity binding of the gRNA dimer to the NC domain. Several GAG proteins interact with a dimer of genomic RNAs. This complex is transported by actin or microtubule to the plasma membrane where final virion assembly and budding occurs. h3. Virion maturation

Upon virion release the protease is activated and cleaves GAG and GAG-POL polyproteins into individual chains that self-assemble to form the capsid inside the virion. Mutant of Nc are reverse transcribing before budding: Nc would play a role in the trigger of processing/reverse transcription post budding. The capsid can assemble in a cylinder in some virion, those seem to have excluded virus genome form the capsid.

Central Board of Secondary Education has announced Class 10th and 12th Board Exam Date Sheet for 2019. For Class 12th, the examination will start from February 15 and end on April 3. For Class 10th, the exam will commence on February 21 and ends on March 29. The date sheet is available on the official website – cbse.nic.in

CBSE has released the board exam time table seven weeks before the exam date. Students can now check CBSE Board Exam Date Sheet. The Board has made it clear that the exam dates have been fixed in a way that it doesn’t coincide with the dates of competitive exams. The CBSE board exam results 2019 is likely to be released by the first week of June.

NEET PG 2019 Application Form Correction facility started; Last date to edit details is 26 Dec
The National Board of Examination (NBE) has published a notification at its official website in which it has stated that it has received many complaints from the candidates to edit few details in the NEET PG 2019 Application Form. Hence, the Board is providing this one-time opportunity to the candidates in which they can edit few details in the Online application form.

The window for NEET PG 2019 Application Form correction has been started from today onwards. To edit details in the NEET PG 2019 Form, the candidates need to visit the official website of NBE at nbe.edu.in. On the homepage of the official website. click on the link which says “Applicant Login”. Next, the candidates need to click on the tab for Edit Application Form.

WBJEE 2019: Application process begins December 26 at wbjee.in, check details
The online application process for West Bengal Joint Entrance examination will begin from December 26 and the last date for the submission of application form is January 30. The forms will be available at wbjee.in. The entrance exam is scheduled to be held on May 26 while the admit card is expected to be released on May 14. The results will be available on July 2, 2019. To successfully register for the entrance examination, the candidate needs to have a mobile number and a unique email ID. The eligible candidates should have passed class 12 equivalent exam with Physics and Mathematics as subjects from a recognised board.

They should have chemistry/biotechnology/biology/computer science/computer application as compulsory subjects with individual pass marks in all three subjects. The candidates should score at least 45 per cent marks in the above subjects. The reserved category students will get 5 per relaxation in marks. The application fees for WBJEE 2019 is Rs 500. The candidates are advised to keep an eye on the official website for more updates regarding the entrance examination.

AIIMS PG 2019: The All India Institute of Medical Sciences (AIIMS) New Delhi has released the results of post graduate entrance exam which was conducted on November 18, 2018 for the January 2019 session or Admissions on its official website – aiimsexams.org. All the candidates who had appeared for the examination and were eagerly waiting for their results can now check the official website to download the list of the qualified candidates.

Candidates who have appeared for the exam need to log into the portal of AIIMS, i.e. www.aiimsexams.org and check if they have been shortlisted for the counselling to be conducted by the authority. Meanwhile, the AIIMS PG entrance examination was conducted for admission to various MD courses at AIIMS New Delhi, Patna, Jodhpur, Bhubaneswar, Bhopal, Raipur and Rishikesh by the All India Institute of Medical Sciences.
How to check the list of qualified candidates for admission to the January 2019 session?

Visit the official website of All India Institute of Medical Sciences (AIIMS) New Delhi – aiimsexams.org
Look for the link that reads, “Important Announcements” on the homepage
Under the option, click on the link that reads, “Result Notification No.-129/2018- Result for the AIIMS PG Entrance Examination for Jan 2019 Session”
Candidates will be directed to a new window
Now, check the document for the AIIMS PG 2019 result
Download the result and take a print out of the same for reference

AIIMS Postponement of Status of Application Form for the recruitment of Nursing Officer-2018 of AIIMS Bhopal, Jodhpur, Patna, Raipur

West Bengal medical COUNCELLING 2018 notification.....

TENTATIVE SCHEDULE FOR NEET 15% ALL INDIA QUOTA COUNCELLING......

West Bengal HS Result 2018 Released, Active Link on wbresults.nic.in. Granthan Sengupta Tops With 99.2%

NEET result 2018 has been declared. Candidates can check it at cbseneet.nic.in,

NEET 2018 Answer Key: CBSE To Release Answer Key, OMR Today @ Cbseneet.nic.in

The CBSE will display the NEET Answer Key, Images of OMR and Responses to the questions marked by the candidates and Test Booklet Code of the candidates from May 25, 2018.