Cell Migration Gateway

Tissue mechanics regulate brain development, homeostasis and disease.
https://dx.doi.org/10.1242/jcs.191742

Tissue mechanics regulate brain development, homeostasis and disease All cells sense and integrate mechanical and biochemical cues from their environment to orchestrate organismal development and maintain tissue homeostasis. Mechanotransduction is the evolutionarily conserved process whereby mechanical force is translated into biochemical signals that can influence c...

Role of Aquaporin 1 Signalling in Cancer Development and Progression.
https://dx.doi.org/10.3390/ijms18020299

Transfer of malignant traits as opposed to migration of cells: A novel concept to explain metastatic disease.
https://dx.doi.org/10.1016/j.mehy.2017.01.019

Research Specialist, Hanein Lab
A Research Specialist position is available in the Hanein lab at the Sanford Burnham Prebys Medical Discovery Institute
https://sbpdiscoveryhr.silkroad.com/epostings/index.cfm?fuseaction=app.jobinfo&jobid=219172&version=2 #.WG8W2QzEkRs.email ID=219172-891

WNK Kinases in Development and Disease. http://www.sciencedirect.com/science/article/pii/S0070215316301715

Chapter One - WNK Kinases in Development and Disease WNK (With-No-Lysine (K)) kinases are serine–threonine kinases characterized by an atypical placement of a catalytic lysine within the kinase domain. Mutations in human WNK1 or WNK4 cause an autosomal dominant syndrome of hypertension and hyperkalemia, reflecting the fact that WNK kinases are critica...

Glucose-derived AGEs promote migration and invasion of colorectal cancer by up-regulating Sp1 expression.
http://www.sciencedirect.com/science/article/pii/S0304416517300788

Glucose-derived AGEs promote migration and invasion of colorectal cancer by up-regulating Sp1 expression We first observed the co-expression of RAGE, Sp1, and MMP2 in cancer tissue and found that the glucose-derived AGE levels in the serum and tumor tissue of patients with colorectal cancer was increased.

Endothelialization of Rationally Microtextured Surfaces with Minimal Cell Seeding Under Flow.
https://www.ncbi.nlm.nih.gov/pubmed/27346806

Endothelialization of Rationally Microtextured Surfaces with Minimal Cell Seeding Under Flow. - PubMed - NCBI Small. 2016 Aug;12(30):4113-26. doi: 10.1002/smll.201503959. Epub 2016 Jun 27.

On-Chip Quantitative Measurement of Mechanical Stresses During Cell Migration with Emulsion Droplets. https://www.ncbi.nlm.nih.gov/pubmed/27373558

On-Chip Quantitative Measurement of Mechanical Stresses During Cell Migration with Emulsion Droplets. - PubMed - NCBI Sci Rep. 2016 Jul 4;6:29113. doi: 10.1038/srep29113.

Targeted-TERS detection of integrin receptors on human cancer cells.
https://www.ncbi.nlm.nih.gov/pubmed/27722181

Targeted-TERS detection of integrin receptors on human cancer cells. - PubMed - NCBI Cancer Cell Microenviron. 2016;3(4). pii: e1419. Epub 2016 Sep 12.

Cool Tool – Optimize Stem Cell Differentiation in Less Time by Utilizing a Nano Gradient Surface. http://cellculturedish.com/2016/09/optimize-stem-cell-differentiation-less-time-utilizing-nano-gradient-surface/

Optimize stem cell differentiation in less time by utilizing a nano gradient surface

Microscope/Imaging Scientist, Klaus Hahn laboratory, UNC-Chapel Hill.

We are seeking a person to focus on imaging, and to help us develop and maintain novel microscopes. This person will assist in the design and construction of new microscopes, and carry out imaging studies on live cells using biosensors and optogenetics. We currently have scopes with major components assembled in house (single particle tracking, spinning disk confocal, lifetime imaging, 2 photon imaging, spinTIRF, multiplexed imaging, multiplexed biosensors/optogenetics, high content screening, LLSM under construction). A candidate with relevant experience could also participate in software development for microscope automation and image analysis. Experience in any of the following areas would be valuable: cell biology, engineering, optics, microscope automation, lasers, programming, and imaging of live cells or animals. Salary is dependent on experience and background. This position is centered in the Hahn lab, but will involve interaction with other groups focused on microscope development, especially the labs of Richard Superfine at UNC, and the Advanced Imaging Center at Janelia Farm.

Please write to Klaus Hahn at [email protected].

Local alignment vectors reveal cancer cell-induced ECM fiber remodeling dynamics. http://www.nature.com/articles/srep39498

Local alignment vectors reveal cancer cell-induced ECM fiber remodeling dynamics Invasive cancer cells interact with the surrounding extracellular matrix (ECM), remodeling ECM fiber network structure by condensing, degrading, and aligning these fibers.