Inna Gaisler-Salomon Lab

Our paper is out in Translational Psychiatry!
We show that pre-reproductive stress to female rats affects mRNA and miRNA expression in blood and oocytes, and impacts behavior and gene expression in offspring.
Read more here:

Pre-reproductive stress in adolescent female rats alters oocyte microRNA expression and offspring phenotypes: pharmacological interventions and putative mechanisms Pre-reproductive stress (PRS) to adolescent female rats alters anxiogenic behavior in first (F1)- and second-generation (F2) offspring and increases mRNA expression of corticotropin-releasing factor receptor type 1 (Crhr1) in oocytes and in neonate offspring brain. Here, we ask whether the expressio...

מודעות... בקדמת המוח או מאחור?

Are the Neural Correlates of Consciousness in the Front or in the Back of the Cerebral Cortex? Clinical and Neuroimaging Evidence In this Perspective, we will critically review the clinical and neuroimaging evidence for the involvement of the front versus the back of the cortex in specifying conscious contents and discuss promising research avenues.

מה הסיכוי שהסטטיסטיקה תהרוג אתכם?
What are the odds that statistics can get you killed?

האם אפשר לסמוך על סטטיסטיקה? | רן לוי | עושים היסטוריה הפעם ננסה לפענח את הסיבה שבגללה סטטיסטיקה – ואחותה, ההסתברות – זוכות לשם רע כל כך. האם סטטיסטיקאים הם באמת… שקרנים? על חוק בנפורד ואפקט המגירה.

Dopamine... my 2nd favorite neurotransmitter😊

https://www.facebook.com/
ScientificAmericanMind/posts/1299971666733039

Dopamine: The Currency of Desire Rethinking the “pleasure molecule” could help scientists better understand addiction, Parkinson’s disease and motivation

Interesting piece on brain development in adolescence
מאמר מעניין שמסכם ממצאים על המוח בגיל ההתבגרות

http://www.wsj.com/articles/what-teens-need-most-from-their-parents-1470765906?xid=soc_socialflow_facebook_realsimple

What Teens Need Most From Their Parents Recent studies of adolescents reveal what teenagers need most from their parents during four phases of teens’ intellectual, emotional and social development.

Newest publication from our lab... On the effects of social isolation in adolescence.
http://communications.elsevier.com/r/?id=h2ed353d2,feee673,feef069&p1=www.sciencedirect.com/science/article/pii/S0166432816305897

Differential effects of social isolation in adolescent and adult mice on behavior and cortical gene expression A wide range of psychopathology-related behaviors and expression of excitatory, inhibitory and myelin-related markers in mPFC were analyzed.

http://www.nature.com/articles/ncomms12743
Our collaboration with the Akbarian lab at Mt. Sinai....
This study shows how the 3D structure of the genome is affected by the early environment, using a groundbreaking technique that allows to "travel back in time" from the time damage is seen to the time it had actually happened.

Longitudinal assessment of neuronal 3D genomes in mouse prefrontal cortex : Nature Communications : Nature Research Nature Communications | Article Open Print Share/bookmark Cite U Like Facebook Twitter Delicious Digg Google+ LinkedIn Reddit StumbleUpon Longitudinal assessment of neuronal 3D genomes in mouse prefrontal cortex Amanda C. Mitchell1, 2, Behnam Javidfar1, Lucy K. Bicks1, 2, Rachael Neve3, Krassimira G...

Some sad data on mental health funding in the UK:
1/4 people suffer from mental illness in the UK every year, but only 5.8% of funding goes to mental illness. About 300% less than cancer research. I suspect the numbers are very similar to what goes on in the US and Israel. Lose-lose situation.
https://www.mqmentalhealth.org/articles/research-funding-landscape

How much does the UK spend when it comes to mental health research? Mental health research funding analysis

https://www.facebook.com/oripaleducation/posts/1036502849778833
Great movie about the reward system in the brain

Brain Reward: Understanding How the Brain Responds to Natural Rewards and Drugs of Abuse https://www.facebook.com/oripaleducation/posts/1036502849778833

http://www.nature.com/articles/npjschz201622?WT.ec_id=NPJSCHZ-201606&spMailingID=51722551&spUserID=MTI1MzY4NjMxNjEwS0&spJobID=944225390&spReportId=OTQ0MjI1MzkwS0

Molecular evidence of synaptic pathology in the CA1 region in schizophrenia Neurotransmission: Post-synaptic abnormalities in the hippocampus People with schizophrenia have extensive molecular anomalies on the receiving end of synapses in a crucial part of the brain’s hippocampus.