10/04/2019
Cancer researchers from the Wellcome Sangar Institute (https://www.sanger.ac.uk/news/view/new-cancer-drug-targets-accelerate-path-precision-medicine) and Open Targets (https://www.opentargets.org/) are one step closer to developing a more precise and targeted method of cancer treatment and producing the Cancer Dependency Map (DEP map). The DEP map is an exciting project that will, one day, be available to all scientists at a global level. This open database will identify βall the weaknesses or vulnerabilities that exist within different cancer cells and we can use this information to empower the next generation of precision cancer medicines for patients.β Mathew Garnett, Faculty Group Leader, Wellcome Sanger Institute.
CRISPR technology, Analytics and Organoid models (patientsβ tumour cells), have been used to develop the DEP map. So far, the latest findings, from this project, have been published in Nature: https://www.nature.com/articles/s41586-019-1103-9. 324 human cancer models, from 30 cancer types such as the big three global cancers being lung, breast and colorectum (https://www.who.int/cancer/PRGlobocanFinal.pdf) and many other cancer types, 20,000 of the genes have been carefully and painstakingly disabled to investigate the effects of how the cancer grows or doesnβt. Of these thousands of genes, the Wellcome and Open Target scientists, along with GSK, EMBL-EBI and other collaborators, have recently identified about 600 genes that would be targeted for future drug development. The promising findings have been added to the DEP map.
One of these genes that could be targeted by future cancer drugs is called Werner syndrome RecQ helicase (WRN). This has been found to help aid in the survival of cancer cells. If drugs could somehow switch off this gene, would this stop the cancer growth in its tracks or would this only be temporary due to some other genes that will also need to be switched off. (https://www.nature.com/articles/ncomms15180)
This is an incredibly promising time in cancer research especially when the rise in cancer could reach global epidemic proportions https://www.cancer.org/research/infographics-gallery/rising-global-cancer-epidemic.html. According to the WHOβs recent global statistics on cancer epidemiology, 1 in 5 men and 1 in 6 women will develop cancer in their lifetime (https://www.who.int/cancer/PRGlobocanFinal.pdf).
Shockingly in the UK, β1 in 2 people born after 1960 will be diagnosed with some form of cancerβ¦β https://www.cancerresearchuk.org/health-professional/cancer-statistics-for-the-uk -Three
The datasets produced in this new study lay the foundations for producing the Cancer Dependency Map,*** a detailed rulebook for the precision treatment of cancer.