13/08/2026
📢 Publication Announcement
We are pleased to announce that Professor Esther Chan’s team's from HKU’s Department of Pharmacology and Pharmacy has published, "Real-World Effectiveness and Safety of Direct Oral Anticoagulants Versus Warfarin in Patients With Atrial Fibrillation and Mitral Stenosis: A Target Trial Emulation," in Annals of Internal Medicine — a leading peer-reviewed medical journal distributed to over 163,000 American College of Physicians members and read by clinicians and researchers worldwide. Professor Rainer from the Department of Emergency Medicine was honoured to collaborate in the project and to play a part in its success.
This study employs a target trial emulation framework to generate real-world evidence on anticoagulation strategies for patients with atrial fibrillation and coexisting mitral stenosis, addressing a critical gap in current clinical evidence where randomised trial data remain limited.
The findings contribute meaningfully to informed clinical decision-making and patient safety in cardiovascular medicine.
🔗 Access the article: https://www.acpjournals.org/doi/10.7326/ANNALS-25-04740
We congratulate Prof. Chan, Prof. Rainer and all the authors on this significant achievement.