14/09/2026
What happens when an infection triggers the body’s inflammatory system to turn against itself? 🦠🫁
Professor Paul Dark explains how research at the University of Manchester is working towards earlier, more accurate diagnosis and more tailored treatment for sepsis.
Respiratory tract infections are the most common cause of sepsis in the UK and worldwide. Infections such as pneumonia can become life-threatening, particularly in people who are older, have weakened immune systems or live with chronic lung conditions.
Manchester researchers have spent almost two decades investigating whether blood tests can help clinicians recognise infection and guide treatment safely.
The findings have contributed to international recommendations on using procalcitonin to support decisions about stopping antibiotics. They could also inform future NICE guidance and how sepsis is treated across NHS hospitals.
The longer-term ambition is to develop more personalised care for severe respiratory infection and sepsis, with innovation in every breath.