Cambridge Transmissible Cancer Group

Cambridge Transmissible Cancer Group

Share

Our research is on two unusual cancers, known as the canine transmissible venereal tumour (CTVT) and the Tasmanian devil facial tumour disease (DFTD).

The goal of our lab is to understand how cancers can become transmissible.

14/11/2024

Introducing our next nominee for our Golden Star Award 2024.

To vote for Dr Mohammadzai like and share this photo and tell us why you think he deserves to be this year's Golden Star.

Don't forget to follow Worldwide Vets to keep up to date with the award!

Nominator's quote: "Dr Mohammadzai, Dr Mo as he is know at Mayhew, is the epitome of of our organisation, dedicated to helping animals and improving life for both animals and people where he leads projects.
Having qualified as a vet in Kabul in the 1990s he came to UK shortly afterwards. He was determined to work with animals and found Mayhew in London where he started volunteering. After several years he was employed as Vet Assistant at Mayhew and worked tirelessly at our London Charitable Community clinic caring for animals and serving the public through our free preventative health clinics. He was determined to continue to help animals in his home country, Afghanistan and became a channel of communication between UK animal welfare organisations and Kabul authorities to rescue the animals in Kabul Zoo at the beginning of the 2000s. Having
re-established relations with Kabul University Vet Faculty,Mayhew started their international programmes and he travelled to Kabul to provide vet training in small animal health and welfare for the University. Seeing the number of roaming dogs in Kabul, which had escalated after years of conflict and concerned by the number of rabies cases, Dr Mo advised the authorities on how to
address the issues. For years the Kabul authorities had culled thousands of dogs using strychnine poisoning but this had not stopped rabies cases or managed the population. Dr Mo was determined
to find a solution. He planned and delivered the first comprehensive dog population survey in Kabul in 2015 and from this survey he devised a strategy to work to eliminate dog-mediated rabies in Kabul and manage the dog population humanely. After much negotiation, Dr Mo convinced Kabul Municipality to stop culling and start a mass canine rabies vaccination programme, which started in August 2017. He has directed and managed a team of local Afghan vets and support staff
to vaccinate more than 120 000 dogs across 22 districts of Kabul since then. Since 2021 they have been no confirmed reported cases of rabies in dogs or humans. Working to keep Kabul protected, as
there is evidence of rabies outside of Kabul city and in neighbouring provinces, Dr Mo devised a plan to create a 20km buffer zone around Kabul city limits, counting the dogs in this area and now delivering a mass canine rabies vaccination programme to create aprotective ring around Kabul so that the rabies virus does not come into the city. In 2019 Dr Mo introduced a TNR programme for the city, with his team neutering on average 10 000 dogs/year. Under his direction, the team have just passed the milestone of 50 000 dogs neutered in Kabul. Annual dog surveys have been carried
out and 70% of the dog population in the 16 central districts of Kabul has now been neutered. From the Kabul vet clinic, Dr Mo has provided training in small animal reproductive surgery to hundreds of Kabul vets and vet students and helped to delivered a Community Engagement programme for the people of Kabul,raising awareness about rabies, dog bite prevention and how to behave
around the roaming dogs in the city, reaching more than 10 000 people since 2018.

Dr Mo lead the Mayhew Afghanistan team through regime change and remained resolute to continue caring for the dogs of Kabul as long as it was safe to do so.

Beyond Afghanistan, Dr Mo has delivered vet training and advised on clinic design, set up and flow for other NGOs and charities in resource limited countries such as Iraq, Tunisia, Algeria, Georgia, Romania, Russia and India.

Dr Mo is a hugely gifted vet, animal welfare ambassador and programme manager, and a very humble, genuine, caring person. What he has done for animals wherever he has worked but particularly for the dogs in Kabul and for the veterinary profession there is outstanding
and he very much deserves the accolade of a Golden Star Vet Award."

A word from Dr Mo: "Being nominated for an award recognising my efforts in helping animals and people fills me
with a deep sense of pride and gratitude. It’s a validation of the hard work, dedication,
and passion I’ve poured into this mission, often without expecting anything in return. To be acknowledged in this way is both humbling and inspiring.

From the start, my goal has always been simple: to make a difference in the lives of animals and humans alike. This nomination, though, serves as a reminder that others see and value this impact too.

It’s a recognition not just of me, but of the communities, organisations and individuals who have supported this cause alongside me. Without the volunteers, donors, and advocates who believe in this work, none of this would have been possible.

Most of all, this nomination motivates me to keep going. There’s still so much work to be done, so many animals to save, and so many people who need help. This acknowledgement gives me the energy and encouragement to continue fighting for those who don’t have a voice. It’s an honour that I will cherish, and it pushes me to make an even greater difference moving forward"

Voting closes on the 14th of November- be sure to vote for your animal hero before then!

Canine transmissible venereal tumour: the contagious cancer that conquered the world 09/03/2021

A new study by the Transmissible Cancer Group published in Nature Communications!

https://www.nature.com/articles/s41467-020-16765-w.epdf?sharing_token=ot_EFJSFWzjBfUWl7D0LLdRgN0jAjWel9jnR3ZoTv0N5mK2o2XM-3g4UzzNdOhUc6BizN1cGSKkVB6XryAeqqBnT29yVm7HmqYlflBRTVdR3SEs-1ThsNoTdBBfyvKkLTS_RdCqUJyWTeoktPST9U38RV9k7aH-XFHuetd7KCJw%3D

Previous research has shown that at several points in history, mitochondria - which are compartments providing cells with their energy - from unrelated host dogs have been captured by CTVT, perhaps to aid survival of this long-lived cancer lineage. The capture of mitochondrial DNA (mtDNA) by canine transmissible venereal tumour (CTVT) creates a unique opportunity to understand the competitive dynamics of two types of mtDNA juxtaposed within the same cell.

In a new study, published in Nature Communications today, we show that one particular type of mtDNA - named A1d1a - has been recurrently captured by CTVT cancer cells on eleven independent occasions. A1d1a is highly over-represented for CTVT mitochondrial capture compared with its frequency in the dog population. Genetic analysis of this mitochondrial type revealed the presence of an insertion at position 16660 of the mtDNA, which appears to reduce transcription - or the reading - of the mtDNA. We propose that A1d1a mitochondria unexpectedly win the race through a ‘selfish’ replicative advantage - by replicating more efficiently - rather than by providing a functional advantage. Apart from providing insights into the characteristics enabling the spread of this cancer that has ‘metastasised’ on a global scale, this work is of much broader importance, as understanding the competitive dynamics of mtDNA is crucial for advancing knowledge of mtDNA genetic disease and assessing the risks of therapeutic mtDNA transplantation in human embryos.



This work was carried out at the Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge. Thanks to veterinary collaborators from across the globe, the team collected and analysed 539 CTVT tumours from 43 countries in this study. If you would be interested to participate in future studies carried out by the Transmissible Cancer Group as a collaborator through collecting CTVT samples, or if you have any further questions, please, do not hesitate to contact us!


Article citation: Strakova, A. et al. Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer. Nat Commun 11, 3059 (2020).

The article is featured in the Nature Communications Editors’ Highlights!

Interested further? See where this story began:
https://youtu.be/CV9xGi8-p0o

Canine transmissible venereal tumour: the contagious cancer that conquered the world Genetics of a canine transmissible tumour show how the world’s oldest cancer “metastasised” through the global dog population – and captured, maintained and ...

Evolution and lineage dynamics of a transmissible cancer in Tasmanian devils 05/03/2021

A new paper, published in PLOS Biology, from the Transmissible Cancer Group at the University of Cambridge Department of Veterinary Medicine reveals how a transmissible cancer has spread through the Tasmanian devil population, and how this cancer’s genome has evolved and diversified during it evolution.

Evolution and lineage dynamics of a transmissible cancer in Tasmanian devils Tasmanian devils are threatened by devil facial tumour 1 (DFT1), a transmissible cancer clone that spreads between animals by biting. A new study of more than six hundred DFT1 tumour genomes reveals this cancer’s evolution and lineage dynamics over a fifteen year period.

Could cancer drugs help save the Tasmanian devil? 03/04/2020

Human anti-cancer drugs could help treat transmissible cancers in Tasmanian devils

Could cancer drugs help save the Tasmanian devil? Transmissible cancers are incredibly rare in nature, yet have arisen in Tasmanian devils on at least two separate occasions. New research from the University...

Somatic evolution and global expansion of an ancient transmissible cancer lineage 03/04/2020

Our new paper "Somatic evolution and global expansion of an ancient transmissible cancer lineage" was published. https://science.sciencemag.org/content/365/6452/eaau9923 Congratulations to , TCG members and our wonderful collaborators! So exciting to trace the incredible history of CTVT.

Somatic evolution and global expansion of an ancient transmissible cancer lineage Canine transmissible venereal tumor is one of the few cancer lineages that is transferred among individuals through contact. It arose millennia ago and has been evolving independently from its hosts ever since. Baez-Ortega et al. looked at the phylogenetic history of the cancer and describe several....

2019 TCG Xmas parties 03/04/2020
03/04/2020
Want your school to be the top-listed School/college in Cambridge?

Click here to claim your Sponsored Listing.

Location

Category

Address


Department Of Veterinary Medicine, Madingley Road, University Of Cambridge, UK, CB23 7UE
Cambridge
CB30ES