18/09/2026
The ARISTOTLE trial investigated whether adding the chemotherapy drug irinotecan to current treatment of radiotherapy could improve outcomes for patients with high-risk re**al cancer before surgery.
The study, published in Lancet Oncology by researchers including Dr Leslie Samuel from the University of Aberdeen, found that adding irinotecan did not improve patients’ chances of remaining cancer-free after treatment and was associated with more side effects.
While the trial found no benefit from adding irinotecan, it delivered important and lasting benefits for cancer care across the UK:
- A comprehensive quality assurance programme was introduced to ensure treatments were planned and delivered safely and consistently across participating centres. This has since benefited patients across the UK, including in North-east Scotland.
- Workshops across the UK brought together experienced consultants, doctors and radiotherapy professionals in training, helping to embed these approaches into routine practice and support future generations of cancer specialists.
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