EpiGeneSys FP7

A new modeling approach to define the range of chromosome configurations present in a cell population and explore their impact on gene regulation by Edith Heard and Guido Tiana. http://www.cell.com/cell/abstract/S0092-8674%2814%2900361-4

www.cell.com

Register now for the Models, Epigenetics and Evolution 2014, an EpiGeneSys TAB workshop http://www.epigenesys.eu/en/activities/upcoming-epigenesys-activities/icalrepeat.detail/2014/05/22/278/-/models-epigenetics-and-evolution-2014-an-epigenesys-tab-workshop

Models, epigenetics and evolution 2014 - An EpiGeneSys TAB workshop | Epigenesys An ambitious EC-funded research initiative on epigenetics advancing towards systems biology

You want to know more about lysine methylation and the relationships between this histone mark and chromatin replication? Go take a look at the following review: http://www.sciencedirect.com/science/article/pii/S1874939914000698

Histone lysine methylation and chromatin replication Note to users: Uncorrected proofs are Articles in Press that have been copy edited and formatted, but have not been finalized yet. They still need to be proof-read and corrected by the author(s) and the text could still change before final publication.

"The fly transcriptome is substantially more complex than previously recognized". Learn more in Nature http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12962.html
Indeed, more genes and transcripts have been identified in Drosophila.

Diversity and dynamics of the Drosophila transcriptome : Nature : Nature Publishing Group Nature | Article OpenPrintEmailShare/bookmarkCiteULikeFacebookTwitterDeliciousDiggGoogle+LinkedInRedditStumbleUponNext articleNature Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides Diversity and dynamics of the Drosophila transcriptomeJames B. Brown1, 2, 13Nath...

Modelling Approaches in Epigenetics 2014 workshop with
http://www.epigenesys.eu/en/activities/upcoming-epigenesys-activities/icalrepeat.detail/2014/03/20/274/-/modelling-approaches-in-epigenetics-2014-an-epigenesys-and-blueprint-joint-workshop

It will take place in Cambridge the 20th and 21th of march.

Modelling Approaches in Epigenetics 2014 - An EpiGeneSys and BLUEPRINT joint workshop | Epigenesys An ambitious EC-funded research initiative on epigenetics advancing towards systems biology

Call for Abstract: Epigenetics, Chromatin & Transcription (COLD SPRING HARBOR ASIA CONFERENCES): deadline on Feb 23, 2014!!!
http://www.csh-asia.org/2014meetings/EPITRANS.html

CSHAsia 2014 Conference on Epigenetics, Chromatin & Transcription We are pleased to announce the 3rd Cold Spring Harbor Asia conference on Epigenetics, Chromatin & Transcription which will be held in Suzhou, China, located approximately 60 miles west of Shanghai. The conference will begin at 7:00pm on the evening of Monday May 5, and will conclude after lunch on F...

The teams of V. Colot (IBENS, Paris, France) and F. Johannes (GBiC, University of Groningen, Netherlands), show that the physical basis of heredity can also occur in the form of epigenetic marks in Arabidopsis taliana.
http://www.sciencemag.org/content/early/2014/02/05/science.1248127.abstract

Mapping the Epigenetic Basis of Complex Traits Quantifying the impact of heritable epigenetic variation on complex traits is an emerging challenge in population genetics. Here, we analyze a population of isogenic Arabidopsis lines that segregate experimentally induced DNA methylation changes at hundreds of regions across the genome. We demonstra...

Tomorrow, don't forget the 1st Who am I? workshop about epigenetics and evolution in Paris Diderot UNiversity.
http://www.labex-whoami.fr/en/news/280-epigenetics-and-evolution-who-am-i-workshop

News The first Who am I? workshop - epigenetics and evolution: four different perspectives - will be held on January 22, 2014 from 10.30am to 4pm.

Learn the bases of genetics and epigenetics by looking at Jonathan Weitzman talk during the WikiStage experience around the Curiosity theme.
http://www.youtube.com/watch?v=_Nek_3iNtW8

Who am I (genetically)? Jonathan Weitzman - WikiStage ESCP Europe Your own WikiTalk? Your own WikiStage event? Watch more talks? Go to: www.wikistage.org

Happy new year to all!

Transcription Recovery after DNA Damage Requires Chromatin Priming by the H3.3 Histone Chaperone HIRA
http://www.sciencedirect.com/science/article/pii/S0092867413010234
A cell paper published by S. Adam, S.E. Polo and G. Almouzni in 2013 (Cell 155, 94–106. Doi :10.1016/j.cell.2013.08.029)

How transcription restarts in chromatin regions that have been silenced in response to DNA damage remains poorly understood. Here, they show in human cells that the histone chaperone HIRA deposits newly synthesized H3.3 histones at sites of UVC irradiation in a manner coupled to early ubiquitylation events associated with DNA damage detection. This early and transient function of HIRA is required for transcription reactivation once repair is complete and thus, they propose that HIRA-mediated histone deposition can act as a chromatin bookmarking system for transcription recovery after genotoxic stress.

Transcription Recovery after DNA Damage Requires Chromatin Priming by the H3.3 Histone Chaperone... S. Adam, S.E. Polo and G. Almouzni (Cell, 2013, 155, 94–106. Doi :10.1016/j.cell.2013.08.029)

A. Tanay and S. Hadjur, 2 members, published the role of cohesin in the organization of chromosomal domain architecture in The EMBO Journal http://www.nature.com/emboj/journal/vaop/ncurrent/full/emboj2013237a.html

Cohesin-mediated interactions organize chromosomal domain architecture - The EMBO Journal Sevil Sofueva, Eitan Yaffe, Wen-Ching Chan, Dimitra Georgopoulou, Matteo Vietri Rudan, Hegias Mira-Bontenbal, Steven M Pollard, Gary P Schroth, Amos Tanay and Suzana Hadjur