Donostia International Physics Center

Donostia International Physics Center

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BERC Basque Excellence Research Centre

Chromatin Loop Extrusion and Chromatin Unknotting 23/11/2018

Chromatin Loop Extrusion and Chromatin Unknotting It has been a puzzle how decondensed interphase chromosomes remain essentially unknotted. The natural expectation is that in the presence of type II DNA topoisomerases that permit passages of double-stranded DNA regions through each other, all chromosomes should reach the state of topological equili...

Are TADs supercoiled? 21/11/2018

Are TADs supercoiled? Abstract. Topologically associating domains (TADs) are megabase-sized building blocks of interphase chromosomes in higher eukaryotes. TADs are chromosomal regi

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