Microbiomicsehu

EUSK/ Gaur gure ikerketa taldea berriro komunikabideetan!! 📣📰
Hauetan Leire Aparicio-ren 👩🏼‍🔬, gure taldeko ikerlari eta irakaslearen lana aitortzen da, Candida albicans onndoak minbizi-zeluletan duen eraginari buruzkoa! 🍄🦠
Ez galdu! 👇

CAST/ ¡Hoy nuestro grupo de investigación vuelve a estar en los medios! 🗞️🙌
Estas noticias destacan el trabajo de Leire Aparicio 👩🏼‍🔬, investigadora y profesora de nuestro grupo, sobre el impacto del hongo Candida albicans en las células cancerígenas. 🏥🦠
¡No os lo perdáis! 👀✨

ENG/ Today, our research group is once again in the media! 🌍📢
The coverage highlights the work of Leire Aparicio 👩🏼‍🔬, a researcher and teacher in our group, on the impact of the fungus Candida albicans on cancer cells. 🍄🦠
Don’t miss it! 👇

🔗 LINKS:
https://www.deia.eus/actualidad/sociedad/2026/02/03/investigadores-ehu-hallan-impacto-negativo-10651801.html

https://www.ehu.eus/eu/web/campusa/-/gure-gorputzean-bizi-den-onddo-batek-melanoma-agresiboago-bihurtzen-duela-argitu-dute

Investigadores de EHU hallan el impacto negativo que un hongo humano añade al melanoma El estudio ha demostrado que se conforma un entorno con condiciones propicias para que las células malignas obtengan más oxígeno y energía

🦠 Viruses and bacteria have long been linked to cancer… but what about fungi? 🍄

In our new study, we explored the impact of the pathogenic fungus Candida albicans on melanoma cells. 🔬

The result? 🚨 The presence of the fungus drives a more aggressive phenotype and higher metastatic potential. It activates the p38-MAPK/c-Fos inflammatory pathway and shifts cellular metabolism toward aerobic glycolysis. ⚡️🧬

These findings offer fresh insights into the potential role of fungi in human carcinogenesis. 🧠✨

Special thanks to our collaborators .eus for their crucial support in this research

🔗 Link to read the full article! https://www.nature.com/articles/s41598-025-24055-y



//EUSK
🦠 Birusak eta bakterioak minbiziarekin lotu izan dira aspalditik... baina zer gertatzen da onddoekin? 🍄

Gure ikerketa berrian, Candida albicans onddo patogenoak melanoma zeluletan duen eragina aztertu dugu. 🔬

Emaitza? 🚨 Onddoaren presentziak fenotipo erasokorragoa eta potentzial metastatiko handiagoa eragiten du. Prozesu honek p38-MAPK/c-Fos hantura-bidezidorra aktibatzen du eta metabolismo zelularra glikolisi aerobikora bideratzen du. ⚡️🧬

Aurkikuntza hauek ikuspegi berriak eskaintzen dituzte onddoek giza kartzinogenesian izan dezaketen paperari buruz. 🧠✨

🔗 Esteka artikulu osoa irakurtzeko! https://www.nature.com/articles/s41598-025-24055-y

Mila esker gure kolaboratzaileei .eus ikerketa honetan emandako laguntzagatik!

The remarkable resistance of Candidozyma (Candida) auris to different environmental stresses, including oxidative stress, plays a crucial role in its pathogenesis.
🔍 In our new study recently published in Microbiological Research, we identified that the Tsa1b peroxiredoxin of C. auris is upregulated at both the protein and gene expression levels in the presence of H₂O₂, and that it contributes to the virulence of the fungus, as demonstrated in in vitro and in vivo infection models.
💡 These findings provide new insights into the defense mechanisms and pathogenicity of C. auris, an emerging pathogen of major clinical concern.
📖 Read the full article: https://www.sciencedirect.com/.../pii/S094450132500312X

New PhD in the group!! Congratulations Dr. Uxue Perez-Cuesta!! Zorionak doktore berria!!

Check out our latest publication! 🔥

In this study, we identified the most immunoreactive antigens of Candida auris recognized by sera obtained from mice and patients with C. auris systemic infection, and their specificity was confirmed using sera obtained from mice with disseminated infections caused by Candida albicans and Aspergillus fumigatus.

In vivo infection & Histology & ImmunoProteomics

📄Article available here:
https://pubs.acs.org/doi/full/10.1021/acs.jproteome.3c00752

Congratulations Maialen Areitio Beramendi!

First evidence on the immune and metabolic response of hepatic endothelial cells against the fungus Candida albicans. Check out our latest publication 👉🏻 https://doi.org/10.1016/j.micinf.2024.105305

Today is the International day of Women and Girls in Science! The world needs Science, and Science needs women and girls! Here some of our colleges from MikroIker Ehu and Microbiomicsehu

Sensible y Resistente podcast. Bacteriemias: el Santo Grial de las Enfermedades Infecciosas https://campus.seimc.org/cursos/detalle/sensible-y-resistente-podcast/290