Aging Research and Drug Discovery

Our first paper with Dominika Wilczok is now out in the journal of the American Society of Clinical Pharmacology. This paper looks at the many inefficiencies in the AI-powered drug discovery industry and explains why we have not yet seen the first AI-discovered drug reaching approval even in the scenarios where companies cut corners by in-licensing or repurposing existing drugs for going after old targets. It contains valuable advice for the AI drug discovery and pharma companies as well as to the regulators. In the new year, let's work together to accelerate this industry and make real change.

Referenced the work by the St Gallen Consortium Alexander Schuhmacher and Oliver Gassmann, BCG Madura Jayatunga and Chris Meier, BiopharmaTrend, Andrii Buvailo . and other analysts.

The pharmaceutical industry lacks benchmarks on the preclinical R&D side. Trillions of dollars spent over decades and AIDD companies, investors, and pharma companies don't know what to optimize for and how to evaluate the companies. There are very few studies looking deep into preclinical R&D, time, cost, POS, and, most importantly, novelty, and potential patient and market impact.

Without real benchmarks we will have many naked emperors walking around and since the program timelines often span decades and multiple carriers, no one will be held accountable and responsible.

Progress, Pitfalls, and Impact of AI‐Driven Clinical Trials Since the deep learning revolution of the early 2010s, significant efforts and billions of dollars have been invested in applying artificial intelligence (AI) to drug discovery and development (AIDD)...

New important paper in AI-powered drug discovery and aging research with experimental validation:

A small-molecule TNIK inhibitor targets fibrosis in preclinical and clinical models - Nature Biotechnology An AI-generated small-molecule inhibitor treats fibrosis in vivo and in phase I clinical trials.

Dear all, two more days left to register for a potential short talk at the 10th ARDD. 100+ speakers. 400 on-site. Poster and travel awards. Get a ticket before your neighbor! Space is limited.

ARDD 2023 In this symposium, leaders in the aging and longevity field will describe the latest progress in the molecular, cellular and organismal basis of aging and our search for interventions. A panel of thought-leaders will give us their cutting edge reports on the latest progress in our quest to extend th...

So much great content from the 9th Longevity VC Panel moderated by Insilico Founder and CEO Alex Zhavoronkov with the participation of Alex Bause, co-Founder at Apollo Ventures, Kristen Fortney, CEO and co-Founder at BioAge, James Peyer, PhD, CEO at Cambrian BIO, Anastasia Georgievskaya, CEO at Haut.AI, Garri Zmudze, Longevity Science Foundation, Laurence Ion, VitaDao

We're taking you to the Ceremonial hall of the University of Copenhagen to see the speakers, delegates, and superstar entrepreneurs inspire each other, share ideas, and collaborate. Morten Scheibye-Knudsen Alex Zhavoronkov

Also, please share your feedback with us so the next time we meet, ARDD2023 is even better! We want to hear what was amazing, and what we could have done differently. Drop your ideas at [email protected]

We're taking you to the Ceremonial hall of the University of Copenhagen to see the speakers, delegates, and superstar entrepreneurs inspire each other, share ideas, and collaborate.

Also, please share your feedback with us so the next time we meet, ARDD2023 is even better! We want to hear what was amazing, and what we could have done differently. Drop your ideas at [email protected]

A glimpse of our amazing speakers at - Björn Schumacher, from the University of Cologne; Andrea Maier, from the National University of Singapore; Ian Hickson from the University of Copenhagen; Matthias Mann from Max Planck Institute for Biochemistry; Joris Deelen from Max Planck Institute for Biology of Aging; Sara Hägg from Karolinska Institutet, Jennifer Garrison from Buck Institute for Research on Aging; Sarah Mitchell from ETH Zurich; Nir Barzilai from Albert Einstein College of Medicine; Kaare Christensen from Danish Aging Research Center and the Danish Twin Registry

was a blast. Grateful for our sponsors, speakers and amazing participants❤️ The event would have been impossible without Morten Scheibye-Knudsen Alex Zhavoronkov and Daniela Bakula

More pics coming soon!