Institute for Nootropic Studies

Bull Exp Biol Med. 2015 Jan;158(3):349-51. doi: 10.1007/s10517-015-2759-2. Epub 2015 Jan 9.

Nootropic dipeptide noopept enhances inhibitory synaptic transmission in the hippocampus.

Povarov IS1, Kondratenko RV, Derevyagin VI, Ostrovskaya RU, Skrebitskii VG.
Author information
Abstract

Application of nootropic agent Noopept on hippocampal slices from Wistar rats enhanced the inhibitory component of total current induced by stimulation of Shaffer collaterals in CA1 pyramidal neurons, but did not affect the excitatory component. A direct correlation between the increase in the amplitude of inhibitory current and agent concentration was found. The substance did not affect the release of inhibitory transmitters from terminals in the pyramidal neurons, which indicated changes in GABAergic interneurons.
PMID: 25573367 [PubMed - indexed for MEDLINE]

http://www.ncbi.nlm.nih.gov/pubmed/25573367

Nootropic dipeptide noopept enhances inhibitory synaptic transmission in the hippocampus. -... Bull Exp Biol Med. 2015 Jan;158(3):349-51. doi: 10.1007/s10517-015-2759-2. Epub 2015 Jan 9. Research Support, Non-U.S. Gov't

Front Neurol. 2013 Sep 11;4:130. doi: 10.3389/fneur.2013.00130. eCollection 2013.
Neuro-modulating effects of honokiol: a review.
Woodbury A1, Yu SP, Wei L, García P.
Author information
Abstract
Honokiol is a poly-phenolic compound that exerts neuroprotective properties through a variety of mechanisms. It has therapeutic potential in anxiety, pain, cerebrovascular injury, epilepsy, and cognitive disorders including Alzheimer's disease. It has been traditionally used in medical practices throughout much of Southeast Asia, but has now become more widely studied due to its pleiotropic effects. Most current research regarding this compound has focused on its chemotherapeutic properties. However, it has the potential to be an effective neuroprotective agent as well. This review summarizes what is currently known regarding the mechanisms involved in the neuroprotective and anesthetic effects of this compound and identifies potential areas for further research.
KEYWORDS:
GABA; amyloid; analgesia; honokiol; inflammatory pain; magnolol; neuroprotection; stroke
PMID: 24062717 [PubMed] PMCID: PMC3769637 Free full text

http://www.ncbi.nlm.nih.gov/pubmed/24062717

Neuro-modulating effects of honokiol: a review. - PubMed - NCBI Front Neurol. 2013 Sep 11;4:130. doi: 10.3389/fneur.2013.00130. eCollection 2013. Review

R-phenibut binds to the α2-δ subunit of voltage-dependent calcium channels and exerts gabapentin-like anti-nociceptive effects.

http://www.ncbi.nlm.nih.gov/pubmed/26234470

R-phenibut binds to the α2-δ subunit of voltage-dependent calcium channels and exerts... Pharmacol Biochem Behav. 2015 Oct;137:23-9. doi: 10.1016/j.pbb.2015.07.014. Epub 2015 Jul 31.

Noopept stimulates the expression of NGF and BDNF in rat hippocampus

http://www.ncbi.nlm.nih.gov/pubmed/19240853

Noopept stimulates the expression of NGF and BDNF in rat hippocampus. - PubMed - NCBI Bull Exp Biol Med. 2008 Sep;146(3):334-7.

Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2013 Jul;29(4):298-300.

[Protective effect of oxiracetam on traumatic brain injury in rats].
[Article in Chinese]
Li JW1, Yang DJ, Chen XY, Liang HQ.
Author information
Abstract

OBJECTIVE:
To study the role of oxiracetam on traumatic brain injury in rats.
METHODS:
Thirty Wistar rats were randomly divided into 3 groups: sham operation group, model group and treatment group. Feeney method were used to establish traumatic brain injury (TBI) model in rats in model and treatment group, and rats in sham group were only broached without hydraumatic fitted. Rats in treatment group were successive administration for 21 days with oxiracetam (100 mg/kg, ig). Neurologic impairment scores were undertook after operation of 1 d, 4 d, 7 d, 14 d and 21 d, and Morris water maze test were proceeded during 15 to 19 days after operation. Average escape latency, searching time in target quadrant and number of crossing target platform in rats were recorded.
RESULTS:
Neurologic impairment scores of rats in treatment group were significantly less than those of model group after operation of 7, 14 and 21 d (P < 0.05). Average escape latency of model group were significantly higher than those of sham operation group and treatment group (P < 0.05, P < 0.01). Searching time in target quadrant and number of crossing target platform of model group were lower than those of sham operation and treatment group (P < 0.05)).
CONCLUSION:
Oxiracetam could decrease neural injury and increase ability of learning, memory and space cognition in traumatic brain injury rats.
PMID: 24175546 [PubMed - indexed for MEDLINE]

Brain Inj. 1991 Oct-Dec;5(4):375-80.

Placebo-Controlled Study Of Pramiracetam In Young Males With Memory And Cognitive Problems Resulting From Head Injury And Anoxia.

McLean A Jr1, Cardenas DD, Burgess D, Gamzu E.
Author information

Abstract

The current study evaluated under double-blind placebo-controlled conditions, the safety and efficacy of 400 mg pramiracetam sulphate TID in treating memory and other cognitive problems of males who have sustained brain injuries. The results of the study indicate that subject performance in measures of memory, especially delayed recall, evidenced clinically significant improvements after the administration of pramiracetam sulphate as compared to placebo. This improvement was maintained during an 18-month open-trial period on the medication as well as during a 1-month follow-up period after the pramiracetam was discontinued.

PMID: 1786500 [PubMed - indexed for MEDLINE]

Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves the attenuation of apoptosis and tau hyperphosphorylation.
http://www.ncbi.nlm.nih.gov/pubmed/25096780

Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves...

http://www.ncbi.nlm.nih.gov/pubmed/8061686

Piracetam and other structurally related nootropics. - PubMed - NCBI Brain Res Brain Res Rev. 1994 May;19(2):180-222. Research Support, Non-U.S. Gov't; Review

Identification and evaluation of the neuroleptic activity of Phenotropil (Phenylpiracetam)
Zh Nevrol Psikhiatr Im S S Korsakova. 2013;113(7):42-6.

..Phenotropil had no sedative action and other adverse effects. It exhibited a positive effect on exploratory behavior and motor activity, had anxiolytic and antidepressant action.

http://www.ncbi.nlm.nih.gov/pubmed/23994920

[Identification and evaluation of the neuroleptic activity of phenotropil]. - PubMed - NCBI Zh Nevrol Psikhiatr Im S S Korsakova. 2013;113(7):42-6. Comparative Study; English Abstract

The original novel nootropic and neuroprotective agent Noopept
Eksp Klin Farmakol. 2002 Sep-Oct;65(5):66-72.

In contrast to Piracetam facilitating only the early stages of the memory process, Noopept positively influences the memory consolidation and retrieval steps as well. The new drug produces an additional selective anxiolytic action...

http://www.ncbi.nlm.nih.gov/pubmed/12596521

[The original novel nootropic and neuroprotective agent noopept]. - PubMed - NCBI Eksp Klin Farmakol. 2002 Sep-Oct;65(5):66-72. Comparative Study; English Abstract; Review

Raiding the Medicine Cabinet to Become Superhuman - Wired - Mind Sciences Network Mind Sciences... Blog Raiding the Medicine Cabinet to Become Superhuman – Wired Share this Post Wired By Peter Rubin |12.17.12 | 6:30 AM Yes, this is really Tim Ferriss. No, he is not really leaping tall buildings.Photo: Doron Gild If you’ve read Tim Ferriss’ books, you know he’ll do almost anything to himself…

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