The Ziemert lab is a research group interested in secondary metabolites from bacteria.
We are developing bioinformatic tools to facilitate genome mining of bacteria to discover new natural products as important drug leads. We also focus on the evolution of these diverse chemical compounds in their natural environments.
21/07/2019
50 years ago today two men walked on the moon, but they may never have made it there if not for Margaret Hamilton.
The software engineer developed the onboard computer programs that powered NASA's Apollo missions, including the 1969 moon landing.
https://www.cnn.com/2019/07/19/us/apollo-11-margaret-hamilton-50th-anniversary-trnd/index.html
21/06/2019
A nice story about Kistamicin Biosynthesis and Evolution. Great work from Evi Stegmann and Max Cryle, thanks for including me in this study :-).
Kistamicin biosynthesis reveals the biosynthetic requirements for production of highly crosslinked glycopeptide antibiotics Kistamicin is a structurally divergent glycopeptide antibiotic (GPA) that contains a unique 15-membered A-O-B ring. Here, the authors obtained a crystal structure of the kistamicin OxyA/X-domain complex and analysed the cyclisation cascade leading to the formation of the A-O-B ring.
Here an article in German about our research:
23/04/2019
Our autoMLST paper is out. Happy tree building everybody!
AutoMLST: an automated web server for generating multi-locus species trees highlighting natural product potential Abstract. Understanding the evolutionary background of a bacterial isolate has applications for a wide range of research. However generating an accurate specie
30/10/2018
See the new dream team of the ! Welcome Direnc and Shrikant !!! Excited for your research to come 😊
Nadine Ziemert on Twitter “See the new dream team of the ! Welcome Direnc and Shrikant !!! Excited for your research to come 😊”
10/10/2018
The Ziemertlab produced its first PhD!!!
Congrats Dr. Alanjary for an awesome thesis and defense with "summa cm laude"! We are very proud of you and will miss you! Also the biggest thanks to the group for organizing and making the hat :-)
24/06/2018
Genome Miners in climbing mood :-)! For our goodbye to Helena we went climbing and zip lining! What fun, we will miss you so much Helena!
01/06/2018
Yay!!! Martina’s work on comparative genomics of secondary metabolites in the genus Amycolatopsis is finally out! Thanks to all co-authors!
Comparative genomics reveals phylogenetic distribution patterns of secondary metabolites in Amycolatopsis species Genome mining tools have enabled us to predict biosynthetic gene clusters that might encode compounds with valuable functions for industrial and medical applications. With the continuously increasing number of genomes sequenced, we are confronted with an overwhelming number of predicted clusters. In...
23/04/2018
Interested in developing bioinformatics tools for natural product discovery? Come join the team:
10/04/2018
The beta version of our auto multi locus species tree (autoMLST) tool is online and running. Happy species tree building 😊:
autoMLST: Automatic Multi-Locus Species Tree Phylogeny is built using all MLST genes from query and reference organisms using either a concatenated gene or coalescent tree method.
29/12/2017
Organizing a conference? Looking for a plenary speaker? Here is a list of female P*s in the field of natural products: https://docs.google.com/spreadsheets/d/11umSEQKpIknwR2dEWgl0hDhAKw7PilFIjFLusinfnU8/edit =0
Additions are highly encouraged! No more excuses!
Women in Natural Products Research Sheet1 Scientists studying natural products( female) Know more women P*s in Natural Product Research? Please submit names and affiliations here:, womeninnpr. ziemertlab. com Please direct questions and comments to the curators: Dr. Nadine Ziemert, Univ. Tubingen, nadine. ziemert@ uni-tuebin...
The program for our workshop is out. A lot of awesome science! Check it out: http://vaamworkshop2017.ziemertlab.com/program.html