Katedra organické chemie PřF UK

Today has the honor to present on

https://www.natur.cuni.cz/fakulta/uchazeci/studium-na-prf/dny-otevrenych-dveri

Dny otevřených dveří — Přírodovědecká fakulta UK Stejně jako každý rok proběhnou i v tomto akademickém roce na Přírodovědecké fakultě UK Dny otevřených dveří, a to v pátek 14. a sobotu 15. ledna 2022. Dny otevřených dveří proběhnou hybridně - tedy kombinací předtočených informací, online chatu a návštěv na fakuultě. V...

Access the webinar via the following link: https://meet.google.com/gcd-jvsf-qjg

Veselé Vánoce and Merry Christmas

Enantioselective Construction of Chiral Bispiro[Oxindole-Pyrrolidine-Pyrazolone] Derivatives via Sequential and One-Pot Mannich/Hydroamination Reaction The atom-economic method for the preparation of novel bispirocyclic compounds containing three fused heterocyclic scaffolds privileged in drug discovery was developed by using a chiral amine-squaramide Mannich reaction and Au(I)-catalyzed hydroamination. The developed synthetic strategy performed ei...

CZ: Vánoční kalendář z článků naší katedry
ENG: Christmas calendar of selected papers of our department

Enantioselective Desymmetrization of 3-Substituted Oxetanes: An Efficient Access to Chiral 3,4-Dihydro-2H-1,4-benzoxazines Herein, we describe a versatile transition metal/oxidant free synthesis of the chiral 2H-1,4-benzoxazines through chiral phosphoric acid (CPA) catalyzed enantioselective desymmetrization of prochiral oxetanes (30 examples) in up to 99% yield and 99% enantioselectivity under mild reaction conditions....

CZ: Vánoční kalendář z článků naší katedry
ENG: Christmas calendar of selected papers of our department

Cross-Coupling as a Key Step in the Synthesis and Structure Revision of the Natural Products Selagibenzophenones A and B Selagibenzophenone A (1) and its isomer selagibenzophenone B (2) were recently described as natural products from Selaginella genus plants with PDE4 inhibitory activity. Herein, we report the first total syntheses of both compounds. By comparing spectroscopic data of the synthetic compounds with rep...

CZ: Vánoční kalendář z článků naší katedry
ENG: Christmas calendar of selected papers of our department

On-Surface Strain-Driven Synthesis of Nonalternant Non-Benzenoid Aromatic Compounds Containing Four- to Eight-Membered Rings The synthesis of polycyclic aromatic hydrocarbons containing various non-benzenoid rings remains a big challenge facing contemporary organic chemistry despite a considerable effort made over the last decades. Herein, we present a novel route, employing on-surface chemistry, to synthesize nonalternan...

CZ: Vánoční kalendář z článků naší katedry
ENG: Christmas calendar of selected papers of our department

Phosphate‐Based Self‐Immolative Linkers for Tuneable Double Cargo Release Click or tap to learn more.