Dia Sul Fer

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DiaSulFer Project – Prevention and treatment of type 1 diabetes Home DiaSulFer Project DiaSulFer is exploring a new approach in the prevention and treatment of type 1 diabetes by suppressing a newly discovered type of iron-dependent cell death called ferroptosis, through the use of specific natural and synthetic hydrogen (per)sulfide donors. We aimed to examine....

Dobro došli na stranicu projekta DiaSulFer. Projekat Dia SulFer je finansiran od Republike Srbije kroz program .
Učesnici projekta su istrazivaci sa , i

Welcome to the page of DiaSulFer project, funded by the Science Fund of the Republic of Serbia. Our team members are researches from the University of Belgrade: Institute of Biological Research "Sinisa Stankovic" , Faculty of Biology and School of Medicine .

The main goal of DiaSulFer is to examine the new approaches in the prevention and treatment of diabetes type 1, with a focus on the suppression of cell death and thus maintenance of the functional population of insulin-producing β-cells as well the cells of the tissues affected by diabetic metabolic complications. We have recently shown that ferroptosis, a newly defined form of iron-dependent cell death, is a mode of cell death involved in diabetes etiology and pathogenesis. This opens a new avenue in the research of the prevention and treatment of this disease, based on the inhibition of the process of ferroptosis. Although initially considered as a toxic gas, H₂S is now recognized as a gasotransmitter, and its reactive metabolites, as important redox signaling molecules that regulate various
(patho)physiological processes through the protein posttranslational modification – persulfidation. This project aims to reveal the pattern of persulfidation, especially of the ferroptosis-related proteins, in a diabetic state, and thus the mechanisms underlying antiferroptotic actions of various donors of H₂S and its reactive species. The results of the project would enable the implementation of new approaches for the suppression of cell death in diabetes, and thus contribute to improving both diabetes prevention and therapy.