ReadCrystal

Cbl-b protein is a type of E3 ubiquitin ligase that negatively regulates immune function and shows great potential as a novel intracellular immune checkpoint drug target.

ReadCrystal Biotechnology has successfully expressed, purified, and crystallized the 38-427 fragment of the Cbl-b protein, which includes the TKB, LHR, and RING domains. We have also accumulated extensive data on the co-crystal structures of this target and its inhibitors. In addition, we have experience with proteins related to the Cbl-b pathway, both upstream and downstream, which allows us to shorten turnaround time to 1-2 months.

For more information on the gallery structure of ReadCrystal, please stay tuned! Discover more: https://www.linkedin.com/pulse/gallery-structurecbl-b-readcrystal-technology-enddc/?trackingId=ltAzS1xzQPaJHwnnpMhsQg%3D%3D

Gallery Structure of ReadCrystal——CBL-B Cbl-b protein is a type of E3 ubiquitin ligase that negatively regulates immune function and shows great potential as a novel intracellular immune checkpoint drug target. ReadCrystal Biotechnology has completed the expression and structural analysis of the Cbl-b target protein.

Exciting News | Electrolyte Fine-Tuning Alters M*F Catalyst's CO2 Reduction Selectivity, MicroED Reveals M*F Structure

On July 26, 2024, Professor Rong Cao's team from the Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, published an article in Angewandte Chemie International Edition. They synthesized a copper-porphyrin-based metal-organic framework catalyst, FICN-8, and explored its CO2 reduction activity under different electrolyte compositions.

The study found that FICN-8 primarily produced CO in the absence of a proton source, while the main product gradually shifted to formic acid (HCOOH) when a proton source was added to the electrolyte. This discovery provides new insights into altering CO2RR product selectivity by tuning the electrolyte composition.

ReadCrystal Biotechnology collected a total of 11 datasets, from which the four best-quality datasets were selected for combined processing, completing the structure resolution in 4 days.

The full paper is available: https://lnkd.in/gdC9zesF

ReadCrystal specializes in structure determination. For more information, visit the following link: https://lnkd.in/gwwywfG2

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Structural analysis services are the core business of ReadCrystal Biotechnology. Relying on advanced equipment and rich experience, ReadCrystal has built a comprehensive technology platform. Utilizing three cutting-edge technologies: X-ray Diffraction, CryoEM-SPA, and MicroED, we provide high-quality, one-stop services for pharmaceutical companies and academic clients.

💡 What problems can structural analysis technology solve?
1. Target protein and small molecule complex structures
2. Antigen-antibody complex structures
3. Enzyme structures and catalytic mechanisms
4. Nucleic acid structures and functions
5. Structures and functions of new biological macromolecules
6. Drug molecule structure determination
7. Inorganic/organic material molecular structures

💡 Why choose ReadCrystal?
1. High efficiency and fast turnaround
2. Completed structural analysis of over 150 target proteins
3. Completed over 500 macromolecular structural analysis projects
4. Ability to collect diffraction data from nano-sized crystals
5. Diversified crystallization solutions covering all single crystal cultivation problems
6. Self-developed data collection and analysis software compatible with MicroED hardware

For more information, visit the following link: https://lnkd.in/gwwywfG2

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MicroED achieves nearly the same high resolution as X-ray crystallography, but requires single crystal samples only at the nanometer scale. This reduction in sample size greatly decreases the difficulty and time needed for protein single crystal cultivation. For the important co-crystal structure analysis in drug development, MicroED significantly reduces the required crystal size, offering many practical advantages.

For more information, visit the following link: https://www.linkedin.com/pulse/benefits-microed-applications-cocrystal-structure-ckwoc/?trackingId=XQCHoZqFSry2J4Q7ScwRTw%3D%3D

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KRAS protein is an important cancer target protein. ReadCrystal has completed the protein expression and structural analysis of multiple KRAS mutation targets. Based on these experimental conditions and available protein inventory, ReadCrystal has shortened the turnaround time to 1-2 months and ensures the successful delivery of the project.

For more information on the gallery structure of ReadCrystal, please stay tuned! Discover more: https://www.linkedin.com/pulse/gallery-structure-readcrystalkras-readcrystal-technology-oasfc/?trackingId=%2FPVtqx5AWzx85%2FGcDVN2tw%3D%3D

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In the realm of biomedicine, understanding the structure of proteins is key to drug development. ReadCrystal, with structural biology at its core, is committed to elucidating the mechanisms of interaction between target proteins and drug molecules.

🔬 Technological Leadership——Leveraging X-ray crystallography, Cryo-EM SPA, and MicroED, ReadCrystal has accumulated a wealth of protein structure data.

🔍 Rich Dataset——Our growing gallery of proteins offers invaluable resources for researchers to delve into the complexities of biomolecules.

📚 Collaborative Research——Whether you are a researcher in academia or industry, explore our protein structure portfolio and connect with us.

Discover more about our protein structures: https://www.readcrystalbio.com/Structures

Delve into the intricate world of drug discovery where structural biology plays a pivotal role. At ReadCrystal, we're committed to advancing drug discovery through a deep understanding of protein structures.

For more information, click here: https://www.linkedin.com/pulse/advancing-drug-discovery-through-structural-biology-r18cc/?trackingId=KbfqntnIREaI19kBP9sAug%3D%3D

ReadCrystal specializes in providing over 100 high-purity, pre-made target proteins, accelerating your timeline for crystallography and functional studies. Our diverse gallery includes kinases, hydrolases, phosphodiesterases, transcription factors, etc.

Need a protein tailored to your exact specs? Our team delivers customized plasmid designs and expert expression & purification services, ensuring optimal protein yield for your experiments through the utilization of diverse expression systems to meet your protein needs.

Our services also include crystallization, structure determination, biophysical characterization and more. ReadCrystal looks forward to working with you!

For more information, visit the following link: https://www.readcrystalbio.com/

Many unknown structures in M*Fs and COFs have been analyzed through MicroED. ReadCrystal specializes in MicroED technology. Our MicroED platform is renowned for its efficiency in rapidly and precisely analyze the structure of nanocrystals and obtain structural information without the need for a long single crystal cultivation process. In addition, MicroED can further test materials such as proteins, peptides, and small drug molecules.

For more information, visit the following link: https://linkedin.com/pulse/structural-analysis-mofs-cofs-through-microed-32t2c/?trackingId=dnn%2F3M9zQ2K8MMaFXe67Kg%3D%3D

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MicroED Technology-Enabled Diffusion Rate Sieving of Propylene and Propane in PCPs Published in "Nature Communications".
ReadCrystal was responsible for the structural analysis work.

For more information, visit the following link: https://linkedin.com/pulse/microed-technology-supports-publication-new-gas-qzpac/?trackingId=1AxlORi6uTDS%2BxAZDhePjA%3D%3D

🏅 Embracing Team Spirit: ReadCrystal's Team-building

ReadCrystal family gathered for an exhilarating team-building event and faced a series of challenges. The event reinforced our values of courage in adversity and relentless pursuit of excellence, propelling us to innovate technologically and deliver outstanding solutions to our clients.

ReadCrystal specializes in structure determination.
Learn more: https://www.readcrystalbio.com/

Great News❗Mastering Chirality with MicroED - the Analysis of Absolute Configuration of Small Molecules

For more information, visit the following link: https://linkedin.com/pulse/microed-technology-analysis-absolute-configuration-bfkbc/?trackingId=E2a3ImCsXEE8NxllNo63cg%3D%3D

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