Tsinghua Medicine 清华大学医学院

From Tsinghua Medicine 清华大学医学院 to the world. Through clinical research exchange at The George Institute for Global Health , #NextGen work with real hospital data and learn how #ClinicalResearch creates real-world impact. #JoinTsinghua and become part of a #GlobalCommunity! 🌍

’s Prof. Pan Yongwei from Beijing Tsinghua Changgung Hospital, along with Prof. Wang Xiumei from School of Materials Science and Engineering, developed a VEGFR2-blocking 3D-printed nerve conduit to regulate the neuro and treat peripheral neuromas. Their study via ScienceDirect offers a promising strategy for chronic nerve pain.

More: bit.ly/4b7wrr5

When GPCR rivals become allies. Reporting in Cell Press, the team led by Prof. Liu Xiangyu reveals that the HIV atazanavir acts as a “molecular glue,” enabling GPCRs to activate G and β-arrestin together. This unexpected signaling mode reshapes GPCR and paves the way for safer, longer-lasting drugs.

For More: bit.ly/4ruWiy6

"Pull one thread and move the whole body." How a single metabolite rewrites our understanding of immunity.

When a local skin infection occurs, your body launches a coordinated global immune response. But how? That's been a stubborn mystery in immunology.

New research from School of Life Sciences and School of Pharmaceutical Sciences at Tsinghua University, published in Nature Magazine reveals that farnesyl pyrophosphate (FPP), a tiny metabolic intermediate, acts as the thread.

After infection, FPP accumulates in keratinocytes and activates TRPV3 channels, sparking a calcium-dependent cascade that ramps up IL-6 and CCL20 production. This amplifies germinal center responses and antibody generation.

The implications are huge: providing insights for the development of vaccine adjuvants and potential therapeutics for SLE.

https://www.nature.com/articles/s41586-026-10167-6?sessionid=

Nature Tsinghua University

Faculty from Tsinghua Medicine and the National Neuroscience Institute came together this week to share cutting-edge work across neurocognitive disorders, neurodegeneration, neuroimmunology, neuroimaging, cognitive neurophysiology, and AI-enabled diagnostics. Excited to see what emerges from these collaborations.

Uncovering a critical mitochondrial mechanism🧬 Prof. Zhu Jiajun's team from School of Basic Medical Sciences and collaborators revealed a key role of mitochondrial TIM22 in iron–sulfur cluster and . It sheds new light and new targets on TIM22-related !

For more: bit.ly/3MI6p46

🧠How much are we missing at lower imaging resolutions? Led by Assoc. Prof. Tian Qiyuan, ’s team from the School of Biomedical Engineering, with University of Oxford, Harvard University, Stanford University, UCSF, shows how diffusion resolution influences short-range association fiber mapping for improved connectomics.

For more: bit.ly/4pNWHuA

What if a pacemaker could last as long as the heart itself?

A research team from Tsinghua University (Li Zhou), the University of Chinese Academy of Sciences (Ouyang Han), and Fuwai Hospital, Chinese Academy of Medical Sciences (CAMS) (Hua Wei) has reported a symbiotic transcatheter pacemaker capable of regenerating electrical energy directly from heart motion—potentially overcoming one of the greatest challenges in cardiac pacing: lifelong energy supply.

By harvesting biomechanical energy through electromagnetic induction and introducing a magnetic levitation energy-cache design, the device minimizes energy loss while eliminating mechanical friction. Its small size enables minimally invasive transcatheter delivery, with good biocompatibility and hemocompatibility for intracardiac use.

In a porcine model of brady-arrhythmia, the pacemaker demonstrated stable energy regeneration and effective pacing during month-long autonomous operation, surpassing the critical energy condition required for lifelong service.

This work points toward a future where pacemakers may operate in symbiosis with the natural heart—powered by the heart itself.

Read more: https://www.nature.com/articles/s41551-025-01604-4?sessionid=

Li Zhou Ouyang Han Hua Wei
Tsinghua University University of Chinese Academy of Sciences Nature Biomedical Engineering Fuwai Hospital

Symbiotic transcatheter pacemaker for lifelong energy regeneration and therapeutic function in porcine disease model - Nature Biomedical Engineering A self-powered symbiotic transcatheter pacemaker that regenerates energy via electromagnetic induction from the cardiac motion demonstrates a month-long operation in a porcine model of arrhythmia and surpasses the critical energy condition for lifelong service.

Prof D**g Jiahong’s team at Beijing Tsinghua Changgung Hospital reported findings on perineural invasion in distal cholangiocarcinoma. The study contributes to research on precision surgery and was published in the Journal of Hematology & Oncology.

Using subcellular-resolution spatial transcriptomics, the researchers constructed the first high-resolution spatial atlas of the perineural invasion microenvironment, uncovering key neural–tumor–immune interactions associated with aggressive tumor behavior.

Read more: https://pubmed.ncbi.nlm.nih.gov/41508044/

Tsinghua University Tsinghua Medicine 清华大学医学院

A subcellular spatial atlas illuminates the microenvironmental remodeling of perineural invasion in distal cholangiocarcinoma - PubMed Distal cholangiocarcinoma (dCCA) arises from the distal bile duct and is anatomically embedded within the pancreatic head, adjacent to abundant autonomic nerve plexuses. This unique location renders dCCA particularly prone to perineural invasion (PNI), a pathological hallmark that contributes to its...