12/11/2020
A Ph.D. position in my lab:https://wiki.hhu.de/display/QTBP/Job+opportunities+@+QTB
One PhD position in the Marie-Curie Initial Training Network "INNOTARGETS": Modelling the metabolism of S. aureus in conjugation with the host
Background
The aim of INNOTARGETS is to train a new generation of early stage researchers (ESRs) in highly innovative approaches to identify metabolic drug targets in pathogenic bacteria, withtechnical skills which are attractive to both industry and academia. In addition to state of the approaches to target identification, they will be equipped with complementary skills deemed important for research team leaders. Each ESR will have an individual profile according to his/her own career dream, and they will be capable of life-long self-directed learning. Twelve ESRs will work closely together in the INNOTARGETS network solving scientific questions related to metabolism of bacteria in the host, mathematical modelling for target identification and toxicity prediction, adaptation of resistant bacteria to treatment, spread of resistance and improved methods for target identification.
Opportunities for one Early Stage Researcher
The Institute of Quantitative and Theoretical Biology at the Heinrich-Heine University Düsseldorf is seeking outstanding candidates for one Early Stage Researcher (ESR).
The successful candidate will develop a genome-scale metabolic model of Staphylococcus aureus. The basis for model development will be more than 50 fully sequenced and published genomes. The model will be interrogated with constraint-based techniques, such as Flux Balance Analysis (FBA), to answer relevant medical questions. These include the prediction of putative targets how metabolism of S. aureus can be interrupted without affecting the human host cells, for which reason the metabolism of host cells will also be considered. Moreover, available expression data will be integrated into the model to assess how metabolic activities change during the cour
The aim of INNOTARGETS is to train a new generation of early stage researchers (ESRs) in highly innovative approaches to identify metabolic drug targets in pathogenic bacteria, withtechnical skills which are attractive to both industry and academia. In addition to state of the approaches to target i...
