Cancer Immunology, from fundamental research to tomorrow's immunotherapy.
04/25/2021
Our last publication already being picked up in the TCR-verse.
The secret lives of T cell receptors and their role in the immune response Canadian immunologists have identified a mechanism that promotes the activation of T cell receptors by altering how one of its components interacts with the cell membrane.
03/23/2021
Here it is folks! Many years in the making! Thanks to Audrey Connolly for her perseverance through it all. And to top it off we made the cover story of Science Signaling!
TMEM16F mediates bystander TCR-CD3 membrane dissociation at the immunological synapse and potentiates T cell activation The cytoplasmic domains of some of the CD3 subunits within the T cell receptor (TCR) complex localize along the inner leaflet of the plasma membrane through electrostatic interactions, thereby inhibiting their phosphorylation and activation. Connolly et al. found that the scramblase TMEM16F, which r...
New CAR-T receptors developed by our group enable the formation of stable immune synapse between the CAR T cells (green) and tumor cells (red) leading to an increase in tumor cell death in vitro. A dying tumor cell can be observed at the top left. See how it shrivels over time due to induced apoptosis.
New CAR-T receptors developed by our group enable the formation of stable immune synapse between the CAR T cells (green) and tumor cells (red) leading to an increase in tumor cell death in vitro.
10/21/2020
Bravo à Audrey Connolly, mon étudiante au Ph.D, qui a soutenu sa thèse aujourd'hui et qui a obtenu son doctorat avec mention d'excellence!
Congrats to Audrey Connolly, my Ph.D student, for successfully defending her thesis and being awarded her doctorate with a mention of excellence!
08/02/2018
Yet another sucessful summer lab retreat. Cheers!
05/03/2018
A new FRET assay to following intracellular conformational change of immune receptors during cell activation. Connolly et al., 2018...TBA
08/01/2017
Something big this way comes...
11/05/2016
Retraite Immuno 2016...
09/13/2016
Here is another picture of the team! Angie in the pic this time and Benoit Barrette out with family.
Go team EEJEES! I'm really proud of you all!
09/12/2016
Congrats to the EEJEES for finishing their first leg of the Grands Défis this past Sunday. This entailed 10km of running up and down the Mount-Royal, totaling more than 178m in elevation. I am really proud of Jordan Quenneville, Audrey Connolly, Rébecca Panes, and Benoit Berrette for participating in this event. A special thank you to Angélique Bellemare who volunteered her time to help out with the organization by serving breakfast. All and all, 100% of the lab members participated in the year's event, the only lab at the institute to do so.
Thank you all who supported us and the institute with your donations. There is still time to give, to do so, please see an earlier post with all the details.
-Etienne, Lab Director, Fundamental and Tumor Immunology, IRIC.