16/03/2020
Informação preliminar, estão a estudar a razão do percurso da doença em Itália ser mais grave. Um dos factores foi a maioria dos doentes ter tomado ibuprofeno em casa. Juntaram o vírus e ibuprofeno no laboratório e chegaram à conclusão que a administração de ibuprofeno acelera a multiplicação do vírus e que está relacionado com percurso mais grave da doença. Recomendam evitar ibuprofeno e administrar paracetamol, aspirina, diclofenac.
E há este artigo que fala um pouco sobre isso.
https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30116-8/fulltext "Human pathogenic coronaviruses (severe acute respiratory syndrome coronavirus [SARS-CoV] and SARS-CoV-2) bind to their target cells through angiotensin-converting enzyme 2 (ACE2), which is expressed by epithelial cells of the lung, intestine, kidney, and blood vessels.4 The expression of ACE2 is substantially increased in patients with type 1 or type 2 diabetes, who are treated with ACE inhibitors and angiotensin II type-I receptor blockers (ARBs).4 Hypertension is also treated with ACE inhibitors and ARBs, which results in an upregulation of ACE2.5 ACE2 can also be increased by thiazolidinediones and ibuprofen. These data suggest that ACE2 expression is increased in diabetes and treatment with ACE inhibitors and ARBs increases ACE2 expression. Consequently, the increased expression of ACE2 would facilitate infection with COVID-19. We therefore hypothesise that diabetes and hypertension treatment with ACE2-stimulating drugs increases the risk of developing severe and fatal COVID-19."
The most distinctive comorbidities of 32 non-survivors from a group of 52 intensive care unit patients with novel coronavirus disease 2019 (COVID-19) in the study by Xiaobo Yang and colleagues1 were cerebrovascular diseases (22%) and diabetes (22%). Another study2 included 1099 patients with confirm...