Hologic Diagenode

[𝗠𝗨𝗦𝗧 𝗥𝗘𝗔𝗗] New insights into AR-GR crosstalk in prostate cancer! This study shows how AR facilitates GR binding through chromatin remodeling (assisted loading), driving synergistic transcriptional responses linked to improved patient outcomes. Hologic Diagenode Tagmentase (Tn5 transposase) was utilized for ATAC-seq assays, enabling precise chromatin accessibility profiling. This work represents a pivotal step in understanding steroid receptor interplay and its therapeutic implications.

Read the full publication: https://lnkd.in/eQukpHaz

[𝗠𝗨𝗦𝗧 𝗥𝗘𝗔𝗗] Excited to share a new study on Brca1-linked breast cancer that leverages our pA-Tn5 for snCUT&Tag data generation. Researchers revealed how epigenomic disruption and partial EMT in luminal progenitors trigger tumor progression, shedding light on early changes that pave the way for invasive disease. This discovery holds promise for advancing early detection strategies and improving outcomes for high-risk individuals.

Read the full publication: https://rb.gy/zo8oeb

[𝗠𝗨𝗦𝗧 𝗥𝗘𝗔𝗗] Excited to share a recent publication featuring our 𝗧𝗻𝟱 𝘁𝗿𝗮𝗻𝘀𝗽𝗼𝘀𝗮𝘀𝗲 in SPACE-seq! This new method enables the simultaneous analysis of multiple molecular features- gene expression, chromatin accessibility, and mitochondrial DNA mutations- using a widely available spatial transcriptomics platform.

Read the full publication: https://rb.gy/0ox82t

Looking for consistent results with Tn5 Transposase?

Introducing our 𝗧𝗮𝗴𝗺𝗲𝗻𝘁𝗮𝘀𝗲 (𝗧𝗻𝟱 𝗧𝗿𝗮𝗻𝘀𝗽𝗼𝘀𝗮𝘀𝗲) 𝘄𝗶𝘁𝗵 𝗦𝘁𝗮𝗻𝗱𝗮𝗿𝗱𝗶𝘇𝗲𝗱 𝗨𝗻𝗶𝘁 (𝗨) — a standardized formulation designed to deliver the same high-quality performance in every batch.

Enjoy reproducible data, streamlined workflows, and renewed confidence in your experiments.

𝗟𝗲𝗮𝗿𝗻 𝗺𝗼𝗿𝗲:
https://go.diagenode.com/l/928883/2025-05-29/5mb6k

Looking for an advanced, low-input histone profiling solution to accelerate your research? Discover our new CUT&Tag Service — a cutting-edge solution offering deeper insights than ChIP-seq, exceptional data quality, high signal-to-noise ratios, and rapid turnaround—all with just a fraction of the cells. 🧬

Learn more at: https://rb.gy/2sy3oj

[MUST READ] Working memory capacity (WMC) depends on dopamine (DA) signaling and is impaired in schizophrenia. A new study shows that D1 receptor stimulation modulates WMC via cAMP/PKA in the fronto-striatal circuit: high doses impair WMC through the mPFC, while low doses enhance it via the striatum and improve deficits in a schizophrenia model. The Bioruptor enabled precise phosphoproteomic profiling, illuminating DA’s molecular impact and guiding targeted therapies.

Read the full publication: https://rb.gy/2c2xol

[MUST READ] Excited to share a new study that utilized our MagMeDIP kit (MeDIP-qPCR) and anti-5mC antibody to investigate how maternal hyperandrogenism drives transgenerational β-cell dysfunction. Researchers identified inherited DNA methylation changes in key insulin secretion genes, providing critical biomarkers and therapeutic strategies to protect future metabolic health.

Read the full publication: https://rb.gy/7e1w5n

We’re thrilled to have participated in the AACR Annual Meeting 2025! It was an incredible opportunity to share our latest technologies and solutions and discuss the future of cancer research with leading experts from around the world. Thank you to everyone who stopped by to learn more about our work—let’s keep pushing boundaries together. 🤝🔬

[MUST READ] Excited to highlight a recent study revealing how radial glia–expressed ITGB8 activates microglia-expressed TGFβ1 to guide microglial development. Using our iDeal ChIP-seq kit for Histones, researchers successfully identified changes in active promoters and enhancers in dysmature microglia—shedding light on the epigenetic mechanisms that shape microglial maturation.

Read full publication: https://rb.gy/1i4gew