Awareness And Medical Research Centre

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Symptoms of Thalasemia :-

The signs and symptoms you have depend on the type and severity of your condition.

Thalassemia signs and symptoms can include:

Fatigue

Weakness

Pale or yellowish skin

Facial bone deformities

Slow growth

Abdominal swelling

Dark urine

Some babies show signs and symptoms of thalassemia at birth; others develop them during the first two years of life. Some people who have only one affected hemoglobin gene don't have thalassemia symptoms.

2- When to see a doctor

Make an appointment with your child's doctor for an evaluation if he or she has any of the signs or symptoms of thalassemia

3- Causes

Thalassemia is caused by mutations in the DNA of cells that make hemoglobin — the substance in red blood cells that carries oxygen throughout your body. The mutations associated with thalassemia are passed from parents to children.

Hemoglobin molecules are made of chains called alpha and beta chains that can be affected by mutations. In thalassemia, the production of either the alpha or beta chains are reduced, resulting in either alpha-thalassemia or beta-thalassemia.

In alpha-thalassemia, the severity of thalassemia you have depends on the number of gene mutations you inherit from your parents. The more mutated genes, the more severe your thalassemia.