MRCP Mastermind

Dangerous Medicine Combos🆘⚠️

🚨• Rifampicin + oral contraceptives → birth control failure
🚨• Theophylline + ciprofloxacin → Theophylline toxicity
🚨• Spironolactone + ACE inhibitors → Hyperkalemia
🚨• Warfarin + NSAIDs → severe bleeding
🚨• Carbamazepine + clarithromycin → carbamazepine toxicity

★ Heerfordt's Syndrome:
-Rare manifestations of Sarcoidosis
-Triad of facial nerve palsy, parotid gland swelling, and uveitis.

Cutaneous xanthoma

★Pattern of sensory motor neuropathy:

1.Symmetric, distal, chronic: Diabetes, alcohol, CMT

2.Asymmetric, painful, acute/subacute: Vasculitic neuropathy, leprosy, HIV

3.Rapid progression: Paraneoplastic, toxic, inflammatory (e.g., GBS, CIDP)

4.Relapsing-remitting: CIDP, autoimmune causes

🥼Causes of vertigo:

🌟Peripheral causes
★Benign paroxysmal positional vertigo
★Vestibular neuritis
★Herpes zoster oticus (Ramsay Hunt syndrome)
★Meniere disease
★Labyrinthine concussion
★Perilymphatic fistula
★Semicircular canal dehiscence syndrome
★Cogan syndrome
★Recurrent vestibulopathy
★Acoustic neuroma
★Aminoglycoside toxicity
★Otitis media

🌟Central causes
★Vestibular migraine
★Brainstem ischemia
★Cerebellar infarction and hemorrhage
★Chiari malformation
★Multiple sclerosis

🥼Psychogenic causes of pruritus:

★Depression
★Delusional parasitosis
★Anorexia nevosa
★Psychogenic excoriation

💥phrenic nerve palsy :

★Choice of Imaging: Fluroscopy
★shows paradoxical movement of diaphragm
★moves upward during inspiration.
★moves downward during expiration.

Clue for Renal Tubular Acidosis:

★nephrocalcinosis: RTA 1
★Hyperkalemic: RTA 4
★Hypokalemic: RTA 1/2
★Rheumatic disease: RTA 1
★Fanconi syndrome: RTA 2

# Causes of primary Adrenal Insufficiency :

★Autoimmune adrenalitis
Isolated adrenal insufficiency
Polyglandular autoimmune syndrome type 1
Polyglandular autoimmune syndrome type 2

★Infectious adrenalitis
Tuberculosis
Disseminated fungal infection
Histoplasmosis
Paracoccidioidomycosis
HIV infection and AIDS
Syphilis
African trypanosomiasis

★Metastatic cancer
Primarily lung, breast, stomach, and colon cancer, or lymphoma

★Adrenal hemorrhage or infarction

★Drugs
Ketoconazole
Fluconazole
Rifampin
Phenytoin
Barbiturates

:

★Beta lactum:
Meropenam, imipenam
Piperacillin-tazobac
Ceftazidime, Cefepime

★Non beta lactum:
Cipro/Levofloxacin
Aminoglycosides

👉Hyperextension of DIP joint+ Flexion of PIP
joint= Boutonniere's deformity
💥seen in Rheumatoid Arthritis