Shoiloboti study group for PG

Extra abdominal causes of Abdominal pain: SSF HAD PCT
S-sickle cell crisis
F-famillial medeterrian fever
H-hypercalcemic crisis
H-hyperlipidemia
H-hsp
H-hereditary angioedema
A-acute intermittent porphyria
P-pnh
C-chronic lead poisoning
T-tabetic crisis in tabes dorsalis

In PDA there is continuos machinery murmur present. explaination: in aorta systolic pressure 120 mmgh,diastolic pressure 80 mmgh.In the pulmonary artery systolic pressure 25 mmhg, diastolic pressure 10 mmhg..As aorta pressure is always high so there is continuos blood flow from aorta to pulmonary artery, so we get continuous murmur..so, no cyanosis+continuous machinery murmur =PDA..

Classification of genetic disorder: 1.A.. Single gene disorder( Mendelian inheritence):AD,AR,X-linked dominant,X-linked recessive,Ylinked disorder.B..Non mendelian/ non classical inheritence disorder: triplet repeat disorder( coding,non coding repeat),mitochondrial inheritance, genome imprinting disorder,germ line mosaicism.. 2.. Chromosomal / cytogenetic disorder: a. structural defect( deletions,translication,ring chromosome etc), b. Numerical disorder(aneuploidy): trisomy= patau, edward,down syndrome, klinefelter, turner syndrome. C.. Polygenic inheritence: both genetic +enviromental factor involvement..eg. cleft palate, DM, HTN etc...

Pulmonary arterial hypertension defined when pulmonary arterial pressure >25 mmHg at rest and >30 mmHg when not at rest....

Novel theraphy for Asthma : # Omalizumab acts against IgE. # Mepolizumab acts against IL-5..

# Novel theraphy for cystic fibrosis important for exam: Orkambi ( ivacaftor +lumacaftor)..

Bilateral facial nerve palsy : Mnemonics. GBS (Gullenbarre syndrome, Borelliosis,Sarcoidosis)..

Sarcoidosis. # sarcoidosis with erythema nodosum is good prognosis... # sarcoidosis causes hypercalcemia bcz macrophage in non caseting granuloma secrets 1@hydroxylase enzyme..

# # Cystic fibrosis due to defect in the CFTR gene located on long arm chromosome 7..

# only oral flouroquinolone acts against pseudononas..

# Hypokalemia causes cardiac arrythmia. # Hyperkalemia causes cardiac arrest..

SBA.. What is the hall mark findings of adrenal crisis? a)shock b)hypoglycaemia c)tachycardia d)postural hypotension e) hypothermia..