Normal wound healing
The inflammatory phase of wound healing lasts for 2 to 3 days. Normal wound healing occurs
in three phases – the inflammatory phase lasts for the first 2 to 3 days, the proliferative phase
lasts for 3 days to 3 weeks and, finally, the remodelling (maturation) phase lasts from the end
of the third week to years.
The inflammatory phase, also called the exudative phase, has no tensile strength to
the wound. It consists of vascular, cellular and enzymatic processes. As a result of the
wound, bleeding, vasoconstriction and thrombus formation occurs. Platelets stick to
the damaged vessel endothelium, releasing adenosine diphosphate (ADP), cytokines,
serotonin, prostaglandins and histamine. This causes vascular permeability, resulting in the
migration of inflammatory cells and macrophages, the latter removing devitalised tissue and
microorganisms. Fibrinogen produces fibrin, which forms the framework for the fibroblastic
activity, which is the second phase.
The proliferative phase lasts from 3 days to the end of the third week. The principal
feature of this is fibroblastic activity with the production of collagen and new capillaries
(angiogenesis) and re-epithelialisation; this is called granulation tissue. This increased
collagen gives the wound almost one-third of its original tensile strength. The third phase of
remodelling constitutes re-arrangement and cross-linking of collagen fibres, which can go on
for years while the wound regains 80% of its original tensile strength.
Important questions for BCS
The page is helpful of those who are candidate of BCS and MBBS Examinations
Normal wound healing
1. The following statements are true
except:
A The inflammatory phase of wound
healing lasts for 5 to 7 days.
B Platelet-rich blood clot and dilated vessels
are typical of the inflammatory phase.
C Fibroblastic activity is the main feature
of the proliferative phase.
D In a tendon injury, fibrous adhesion
between the tendon and its sheath is an
important mechanism of healing.
Charity begins at home
31/07/2022
You will know about it when those people___it.
1)will say
2) say
20/03/2021
He decided to prepare the proposal. (Active)
Make it passive
This group is created only for help who are wanted to get a good job
Solution:
Average for 50 number is 38.
The total is 38×50=1900
The total of discarded number is 45+55=100
Hence the total for 48 number is 1900-100= 1800
So, The new average is 1800÷48=37.5
The average of 50 numbers is 38. If two numbers namely 45 and 55 are discarded, the average of the
remaining number is :
(A) 36.50
(B) 37
(C) 37.50
(D) 38
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