18/02/2021
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Researchers sequenced DNA from two mammoths that lived more than 1 million years ago, including a steppe mammoth (illustrated here), the direct ancestor to woolly mammoths. BETH ZAIKEN/CENTRE FOR PALAEOGENETICS
Mammoth molars yield the oldest DNA ever sequenced
By Michael PriceFeb. 17, 2021 , 11:00 AM
A genetic analysis of long-extinct Siberian mammoths has nearly doubled the record for the oldest DNA yet sequenced. The genetic material, from a creature that roamed frozen lands some 1.2 million years ago, pushes the study of ancient DNA closer to its theoretical limit—and reveals a new lineage of mammoth.
“I love this paper,” says Ludovic Orlando, a paleogeneticist at Paul Sabatier University whose team previously held the record for oldest DNA sequenced, from a 750,000-year-old horse. “I have been waiting since 2013 [for] our world record for the oldest genome to be broken.”
Genetic material breaks down relatively quickly in most environments. The oldest DNA sequenced from humans in Africa dates to about 15,000 years ago; in Europe, scientists have sequenced DNA from a Neanderthal that lived some 120,000 years ago. But the DNA of living things buried in permafrost can persist for much, much longer, as the deep freeze slows chemical degradation.
In the 1970s, Russian paleontologist Andrei Sher discovered a trove of frozen remains at several sites in northeastern Siberia, including a trio of mammoths. Based on the orientation of magnetic materials in the surrounding rocks and the types of rodents found buried alongside them, the researchers estimated that the mammoths had lived about 1.2 million, 1 million, and 700,000 years ago.
The researchers behind the new study drilled out tiny samples from the molar of each mammoth—about a pinch of salt’s worth—and attempted to extract DNA. The ravages of time had degraded the DNA into many