The Clarke Lab for Quantitative Exercise Biology - SFU BPK

19/12/2024

Our paper entitled "A PubMed search filter for efficiently retrieving exercise training studies" has been published by BMC Medical Research Methodologies. The genesis of this study was that I was curious as to whether we could develop a search string in PubMed that led to enriched selection of exercise training studies, amidst all the studies of acute exercise. Our "search filter" obtains improved results compared with commonly used simple strings. I am proud of the efforts that three undergraduate researchers, David Yin, Mikaela Engracia, and Matthew Edema, put forth in completing this study. I thank the BC Association of Kinesiologists for a grant that supported this research.

Background A barrier to evidence-informed exercise programming is locating studies of exercise training programs. The purpose of this study was to create a search filter for studies of exercise training programs for the PubMed electronic bibliographic database. Methods Candidate search terms were id...

16/08/2024

Pleased to share our latest paper, a review of contemporary physiologically based pharmacokinetic-pharmacodynamic models of amino acids in humans. Amino acid and protein metabolism are relatively understudied compared to other macronutrients, but there are some really interesting applications being studied in terms of their roles as nutrients, supplements, and as nutraceuticals that my PhD student TJ McColl and I learned about in writing the review. In addition, some cancer treatment strategies involve depleting amino acids to starve the cancerous cells.

d pharmacodynamic (PBPK-PD) modeling is an emerging tool for studying their complex biology. This review highlights recent PBPK-PD models developed to study amino acid physiology and metabolism and discusses their potential for addressing unresolved questions in the field. Recent findings PBPK-PD mo...

22/06/2024

Congratulations to TJ McColl for successfully defending his PhD comprehensive exam today!

09/05/2024

Moses Jeong, a BSc Honours thesis student in the lab, delivered an excellent talk on his research at the SFU Centre for Cell Biology, Development and Disease Annual Symposium yesterday.

He has adapted a model of how muscles incorporate protein to type 2 diabetes, which has impairments in that process and which leads to a heightened risk of sarcopenia ("diabetic sarcopenia," which you can read more about here: https://pubmed.ncbi.nlm.nih.gov/35429264/)

09/05/2024

New paper from the lab entitled "Critical speed models of high-resolution speed-duration profiles describe peak running demands in soccer": https://journals.sagepub.com/doi/epub/10.1177/17479541241246951

In this study, we generated "high-resolution" speed-duration profiles from GPS data collected from NCAA Div I soccer players, followed by evaluating critical velocity (CV) models for their ability to fit the data and efficiently summarize the profiles. We found that three-parameter CV models adequately fit the data and provide actionable information for describing peak running demands in soccer, which could facilitate the design of practice activities that better prepare players for competition.

This project represented our first substantive foray into the analytics of player tracking data from field-based team sports. Congratulations to the authors, Eli Mizelman, Aaron Pearson, and Dani Chi as well as many others who assisted with the project.

PK , mimetypeapplication/epub+zipPK META-INF/container.xmlU 0D%UMBSAгkt74[DTԝ-l5(b'Bs>[ՕF5,L (DV4gREroTB1_-N^Gt7쩔؁Xg$cBgAוDPK-n

30/11/2023

Searching PubMed for exercise *training* studies amongst all studies involving exercise is harder than it should be. So we set out to develop a search filter to help address this issue. We have posted a preprint while the manuscript goes through the peer review process, and would be happy to entertain any comments or feedback.

Preprint / Version 1 A PubMed search filter for efficiently retrieving exercise training studies # .authors # # David Yin Department of Biomedical Physiology and Kinesiology, Simon Fraser University Mikaela Engracia Department of Biomedical Physiology and Kinesiology, Simon Fraser University Ma...

15/10/2023

We partook in the CSEP annual conference in Calgary, presenting our newest research and spending time with old friends.

28/06/2023

Congratulations to Luke Everard, who successfully defended his Honours thesis today! He tackled a challenging interdisciplinary project in which he created a computational model of how forces from resistance exercise are converted into intracellular signals that drive strength-promoting adaptations. He is continuing on to graduate studies in my lab in the fall and we look forward to the exciting work yet to come!

13/06/2023

New preprint posted to bioRxiv: here we report the development and analysis of a computer model of how leucine, an essential amino acid in our diets, promotes skeletal muscle protein levels. Muscle protein levels are a primary factor determining muscle mass. The model sheds light on how mechanisms operating from whole-body to cellular levels of organization interact to determine how much protein our muscles accrue after feeding. We learned so much through this work, in particular how dynamic our bodies are - we are what we eat! Congratulations to TJ McColl for getting the work through to the manuscript stage!

Skeletal muscle protein levels are governed by the relative rates of muscle protein synthesis (MPS) and breakdown (MPB). The mechanisms controlling these rates are complex and their integrated behaviors are challenging to study through experiments alone. The purpose of this study was to develop and....

14/04/2023

31/03/2023

We're recruiting for a training study using augmented-reality swim goggles in recreational swimmers. Must be local to the Lower Mainland. Please forward to those in your circles who meet the eligibility criteria.