10/09/2026
A groundbreaking structural discovery led by researchers at Saint Louis University School of Medicine is advancing scientific understanding of how microbes regulate nitrogen fixation.
Under the leadership of SLU principal investigator Edwin Antony, Ph.D., postdoc Rajnandani Kashyap, Ph.D. and the team in the SLU Department of Biochemistry & Molecular Biology isolated and purified the nitrogenase protein complex and used high-resolution cryo-electron microscopy to capture its native structure. Their work revealed a previously unknown nitrogenase supercomplex that challenges long-standing assumptions about how this essential enzyme is regulated. The multi-institutional study was conducted in collaboration with researchers at the University of Arkansas and has been published in Nature.
The findings could help inform future advances in sustainable agriculture, biotechnology and green energy while demonstrating the impact of SLU’s investment in advanced research infrastructure and scientific talent.
Discover how the SLU team helped uncover this biological "off switch": https://loom.ly/hPtB8bQ
Access the article published in Nature Magazine and read more here - https://loom.ly/Rxa_Q_o
Bioengineer.org - https://loom.ly/-pmAyEs