Bakar Aging Research Institute - BARI

Today at Buck we hosted FRS speaker, Leanne Jones, who is the inaugural director of Bakar Aging Research Institute at . She gave an inspiring talk on intestinal stem cells and aging.

Nancy Allen and Tien Peng's study reveals that age-dependent NF-kB activation in tissue fibroblasts contributes to by remodeling immune architecture and promoting exhausted T cell populations, which are linked to and . The findings suggest that fibroblasts play a crucial role in orchestrating immune aging, increasing vulnerability to . http://bit.ly/4qlIR4k

Kate Cavanaugh and Orion Weiner's research out now on BioRxiv
identifies a mechanical defect in embryos from aged mothers that impairs implantation. These findings could enhance embryo selection in Assisted Technologies. bit.ly/47tY7V8

Sara LaHue, John Newman, Max Krummel, Neel Singhal, and others recently published in GeroScience an interdisciplinary effort to identify longitudinal transcriptomic changes in adults with delirium hospitalized with -19. Leveraging serial blood draws, the team looked at temporal correlates with development and resolution.

Delirium in hospitalized COVID-19 patients is associated with dynamic changes in peripheral immune gene expression - PubMed Delirium is a neurologic syndrome characterized by inattention and cognitive impairment frequently encountered in medically ill older adults. As a hallmark of age-related brain vulnerability, delirium offers a clinical model to investigate how peripheral immune responses contribute to acute brain dy...

It's wonderful to see the number of outstanding applicants increase each year for our graduate student fellowships in collaboration with the UCSF Hillblom Center for the Biology of Aging. Congrats to this year's recipients!

A recent manuscript published in Journal of Clinical Investigation led by Preeti Yadav from Mallar Bhattacharya's lab in collaboration with other BARI colleagues identifies an immune-mesenchymal circuit that fuels fibrotic metabolism in lung fibrosis.

Myeloid-mesenchymal crosstalk drives ARG1-dependent profibrotic metabolism via ornithine in lung fibrosis - PubMed Idiopathic pulmonary fibrosis (IPF) is a disease of progressive lung remodeling and collagen deposition that leads to respiratory failure. Myeloid cells are abundant in IPF lung and in murine lung fibrosis, but their functional effects are incompletely understood. Using mouse and human lung models,....

Certain brain cells are responsible for coordinating smooth, controlled movements of the body. But when those cells are constantly overactivated for weeks on end, they degenerate and ultimately die. This new observation made by scientists at Gladstone may help explain what goes awry in the brains of people with Parkinson’s disease.

Researchers have long known that a particular subset of neurons die as Parkinson’s disease progresses, but they aren’t sure why. The new work, published in the scientific journal eLife, shows that in mice, chronic activation of these neurons can directly cause their demise. The scientists hypothesize that in Parkinson’s, neuron overactivation could be triggered by a combination of genetic factors, environmental toxins, and the need to compensate for other neurons that are lost.

Read more about this study:

Overworked Brain Cells May Burn Out in Parkinson’s Disease A discovery about the consequence of neuron overactivity could lead to new methods of treating or preventing Parkinson’s disease.

The (Martin) Kampmann Lab recently published in NNature an in vivo CRISPR screening platform that can be applied to the mouse brain. The team effort was led by Biswa Ramani and Indigo V.L. Rose.

CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes - Nature Neuroscience The authors developed an adeno-associated virus-based high-throughput in vivo CRISPR screening platform for endogenous mouse brain cell types. Using this platform, they define genes and pathways essential for neuronal survival.