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04/03/2026

A 68-year-old man is brought to the emergency department due to sudden onset weakness of the right side of his body and difficulty speaking for the past 1 hour. He has a history of hypertension and atrial fibrillation but is not compliant with medications.
On examination:
Right-sided hemiplegia (face and arm > leg)
Right facial droop
Expressive aphasia (understands but cannot speak)
Eyes deviated to the left
Which of the following arteries is most likely occluded?

03/24/2026

A 55-year-old man with recurrent arthritis of both knees presents to his primary care physician for a routine check-up.
Results of urinalysis are negative, but the nurse reports that the urine sample turned dark on standing. Levels of what substance will be most notably elevated in the urine sample from this patient?
A.
Branched amino acids
B. Cystine
C. Homocysteine
D. Homogentisic acid
E. Phenylalanine

03/24/2026

A 6-month-old boy is brought to the physician, because he seems smaller than other babies his age and has occasional vomiting associated with bottle feedings of milk. He was born at home and did not undergo newborn screening. On physical examination, the patient is found to have jaundice, bilateral clouding of eye lenses, and hepatomegaly. The patient also shows signs of developmental delay. Which of the following enzymes is likely to be defective in this condition?
ay-hydroxylase
B. Aldolase B
C. Galactose-1-phosphate uridyltransferase
D. Iduronate sulfatase
E. Transmembrane copper-transporting ATPase

03/24/2026

2-year-old boy presents to his pediatrician with hepatosplenomegaly, failure to thrive, and progressive central nervous system deterioration. Liver biopsy shows that hepatocytes and Kupffer cells have a foamy, vacuolated appearance. The pediatrician suspects that the boy will die by 3 years of age. Which of the following is the function of the metabolic enzyme deficient in this patient?
A.Converts ceramide trihexoside to lactosyl cerebrosid
B.Converts galactocerebroside to cerebroside
C.Converts ganglioside M, to ganglioside M3
D. Converts glucocerebroside to cerebroside
E. Converts sphingomyelin to cerebroside

03/23/2026

Q- Morphine is NOT used in which one of the following conditions due to its unwanted effect on the organ involved?
A-Biliary pain
B-Myocardial infarction
C-Post-appendicectomy
D-Pulmonary congestion

03/23/2026

Q- Treatment with prothrombin complex concentrate (PCC) is recommended in which one of the following conditions?
A-Factor VII deficiency
B-Hemophilia A​
C-Hemophilia B
D-Von Willebrand disease

03/23/2026

Q- A patient presents with chronic cough and dyspnea on exertion. Examination reveals lung crackles, a loud P2 heart sound, and clubbing of the fingers. The patient tells you that he works in electronics manufacturing.
Which of the following is the most likely diagnosis?
A-Asbestosis
B-Berylliosis
C-Byssinosis
D-Silicosis

03/19/2026

Manik Madaan USMLE-STYLE QUESTION LAST QUESTION OF THEY DAY

A 55-year-old man with small cell lung carcinoma develops progressive numbness and burning pain in both feet. Neurologic examination shows absent patellar and Achilles reflexes with preserved muscle strength. MRI of the spine is normal.
Which structure is primarily affected in this patient?
A. Anterior horn cells
B. Dorsal columns of the spinal cord
C. Peripheral motor nerve axons
D. Sensory neuron cell bodies

03/19/2026

USMLE HIGH YIELD: HEME/ONC
4. Dry bone marrow tap - diagnosis?
A. AML
B. Myelofibrosis
C. CLL
D. Multiple myeloma
E. ALL

03/19/2026

USMLE HIGH YIELD: HEME/ONC
3. Bite cells on smear - diagnosis?
A. Hereditary spherocytosis
B. G6PD deficiency
C. Thalassemia
D. Iron deficiency anemia
E. Sickle cell disease

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