10/09/2026
LAST Immediate Management — Airway, Benzodiazepine, Lipid Early
⚠️ Suspect LAST? Move quickly.
The priorities are straightforward: call for help, secure oxygenation and ventilation, control seizures, and get 20% lipid emulsion to the bedside.
Give 100% oxygen and avoid hypoventilation because hypoxemia and acidemia can amplify local anesthetic toxicity. Benzodiazepines are preferred for seizure control. Large doses of propofol should be avoided when significant cardiovascular instability is present.
Most importantly: serious LAST is an indication to begin lipid emulsion therapy early—don’t wait for cardiac arrest.
Every anesthesia location using local anesthetics should have a readily accessible LAST kit and cognitive aid.
📚 Sources: Lavonas et al., Circulation, 2023; Waldinger et al., Drugs & Aging, 2020; ASRA LAST guidance.
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