09/22/2026
Volatile anesthetics affect more than anesthetic depth.
Isoflurane produces dose-dependent coronary vasodilation and has demonstrated myocardial preconditioning effects in experimental and clinical research. That does not mean it can overcome inadequate coronary perfusion pressure, severe stenosis, tachycardia, or excessive hypotension.
A potentially protective anesthetic effect still depends on the physiology surrounding it.
Coronary perfusion pressure remains undefeated.