Farese&Walther Laboratory

Paper planning! Six years of work by the amazing on the table.

Want to learn about fat? Here our attempt: https://www.ibiology.org/biochemistry/lipid-droplets/
Thanks F&W lab for all the work that went into this!

Lipid Droplets • iBiology All organisms have evolved ways to store energy- mostly as fat packaged into lipid droplets. Farese and Walther explain how lipid droplets form in cells and the physiological importance of getting this process right.

Study of lipid metabolism in neurons may offer therapeutic possibilities for neurodegenerative diseases For immediate release: April 13, 2020 Boston, MA – Disrupting the production of a class of lipids known as sphingolipids in neurons improved symptoms of neurodegeneration and increased survival in …

https://apple.news/AWTPfZ4rMQwmOos2PRsrVRw

This = fantastic.

PLEASE SHARE THIS WIDELY! It is the best explanation/illustration I’ve seen on why we need to do SOCIAL DISTANCING — NOW. This strategy REDUCES YOUR RISK and RISK TO OTHERS. Win-win. Without vaccines or drugs, it’s the best weapon we have.

Why outbreaks like coronavirus spread exponentially, and how to “flatten the curve” — The Washington Post The early trickle of new coronavirus infections has turned into a steady current. By creating simple simulations, we can see how to slow it down.

https://www.hhmi.org/news/fat-droplets-play-surprise-role-in-metabolism

Fat Droplets Play Surprise Role in Metabolism Cellular structures once thought to be inactive fat storage centers may actually help regulate metabolism.

Launch of new analytics platform provides access to cutting edge tech for Harvard Chan School scientists November 27, 2019—Scientists across Harvard T.H. Chan School of Public Health got a major upgrade to their toolbox this week with the official launch of the Harvard Chan Advanced Multi-omics Platfo…

The doing of science requires administrative support, and lots of it! Congratulations to department administrator Katrina Soriano for being selected as the 2019 recipient of Harvard Chan’s school Sarah K. Wood Award for Outstanding Staff Performance! Here Katrina hears the news. Thanks to administrators everywhere who help make science happen!

looking for a new colleague to join us in ! Spread the word....

http://jobs.shanghaitech.edu.cn/_s57/_t119/00/00/c4206a0/page.psp?_p=YXM9NTcmcD0xJm09TiY_&keyword=Research%20Associate%20Professor%20in%20Mechanistic%20Metabolism%20Research%20Laboratory%20%20(Drs.%20Robert%20V.%20Farese.%20Jr.%20and%20Tobias%20C.%20Walther),%20SLST

Celebrations! Today several lab members received their “RF” hats, presented by the eponymous lab leader, as the highest lab honor, in recognition of publication of their first-author papers.:) each project in the lab takes many months to years to complete and publish. It feels great to celebrate a contribution to “the wall of knowledge” and to recognize all the perseverance and hard work. Special thanks to for the logo :) @ Farese&Walther Laboratory

A rainy day at photo by

New structural biology insights into Lipid Droplet formation, from Xuewu, Henning and in close collaboration with Maofu Liao at HMS

Cryo-electron microscopy structure of the lipid droplet-formation protein seipin Metabolic energy is stored in cells primarily as triacylglycerols in lipid droplets (LDs), and LD dysregulation leads to metabolic diseases. The formation of monolayer bound LDs from the endoplasmic reticulum (ER) bilayer is poorly understood, but the ER protein seipin is essential to this process.....