20/07/2022
Vitamin D, also known as the “sunshine vitamin,” was identified in the 17th century by Dr. Daniel Whistler and Professor Francis Glisson when they discovered the causative factors of rickets.
Circa 1920, Sir Edward Mellanby worked with dogs raised exclusively indoors. He devised a diet that allowed him to unequivocally establish that rickets was caused by a deficiency of a trace component present in the diet and that cod liver oil (an excellent source of vitamin D) was an effective antirachitic agent.
Along with vitamins A, E and K, vitamin D is a fat-soluble vitamin. Vitamin D actually refers to several different forms. Two forms that are important in humans include:
Vitamin D2 (Ergocalciferol)- derived from plants
Vitamin D3 (Cholecalciferol)- derived from animal products and made in the skin when exposed to sunlight
In addition vitamin D has three analogs, each with different potencies:
Cholecalciferol - 1x
25 hydroxycholecalciferol - 5x
1, 25 dihydroxycholecalciferol - 10x
To learn more about each vitamin and mineral we need to stay healthy, check out the NASM guide to Micronutrients.
SOURCES OF VITAMIN D
Vitamin D can be synthesized in the skin after exposure to ultraviolet light or obtained from the diet either from unfortified or fortified food sources or supplements. Unfortified sources include animal products such as cod liver oil, sardines, mackerel, herring, tuna, salmon, and shrimp. Fortified sources include milk and some brands of alternative milks (rice, soy, almond, etc.).
Some vitamin D researchers suggest that approximately 5–30 minutes of sun exposure between 10 a.m. and 3 p.m. at least twice a week to the face, arms, legs, or back without sunscreen usually leads to sufficient vitamin D synthesis (and that the moderate use of commercial tanning beds that emit 2%–6% UVB radiation is also effective).
Individuals with limited sun exposure need to include good sources of vitamin D in their diets or consider supplements to achieve recommended intake levels.
Vitamin D supplements are also great for counteracting the symptoms of COVID!
METABOLISM
As with many nutrients, vitamin D is absorbed in the small intestine. It is transported through the lymphatic system by chylomicrons and stored in the liver, bone, brain, and skin.
Vitamin D obtained from sun exposure, food, and supplements is inactive and must undergo two hydroxylations in the body for activation. The first hydroxylation occurs in the liver, where vitamin D is converted to 25-hydroxyvitamin D [25(OH)D], also known as calcidiol. The second hydroxylation takes place in the kidneys, where it forms the physiologically active 1,25-dihydroxyvitamin D [1,25(OH)2D], also known as calcitriol.
REQUIREMENTS
The Recommended Dietary Allowance (RDA) for vitamin D ranges from 400-800 IU, depending on age, pregnancy/lactation status, skin color, sun exposure, diseases affecting nutrient absorption, and health status. This RDA is considered a daily intake that is sufficient to maintain bone health and normal calcium metabolism in 97-98% of healthy people.
It is important to note that numerous studies support much higher intakes for the prevention and/or management of a number of diseases, some of which will be mentioned later. These intakes can be as high as 10,000 IU/d, or >10 times the current recommended intakes.
MEASURING VITAMIN D STATUS
Serum concentration of 25(OH)D is the best indicator of vitamin D status. It reflects vitamin D produced in the skin and that obtained from food and/or supplements.
Based on a review of the data on vitamin D needs, a committee of the Institutes of Medicine (IOM) concluded that people are at risk for vitamin D deficiency at serum 25(OH)D concentrations
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