Dr Sadia Muzaffar-OBGYN FCPS clinicals

Dose of mgso4

magnesium sulphate/Dose/antidote dose of magnesium sulphate sulphate dose of mgso4

Magnesium sulphate mechanism.of action

Mechansim of action of magnesium sulfate/Eclampsia/pre Eclampsia mechanism of action of magnesium sulfate in detail

Fetal.complucations of

Pre eclampsia symptoms and complications

Antenatal care in pre eclampsia

Nice guideline

guidline

Mechanism of action of

Mechansim of action of magnesium sulfate/Eclampsia/pre Eclampsia mechanism of action of magnesium sulfate in detail

Mechanism of action of

Effect of magnesium sulfate on cerebral edema and the blood-brain barrier. The calcium antagonistic effects of magnesium can also affect the cerebral endothelium that forms the blood-brain barrier. Decreased cell calcium inhibits endothelial contraction and opening of tight junctions that are linked to the actin cytoskeleton. Decreased tight junction permeability limits paracellular transport of vascular contents, ions, and proteins that can promote vasogenic edema and seizures. It is also possible that magnesium sulfate diminishes transcellular transport by limiting pinocytosis, which is known to occur rapidly during acute hypertension. Magnesium may also downregulate aquaporin 4 (AQP4), a water channel protein localized to astrocytic endfeet, and possibly cerebral endothelium, which is associated with cerebral edema formation (through unknown mechanisms)

of action of

Anticonvulsant activity of magnesium sulfate. Seizures consist of an excessive release of excitotoxic neurotransmitters including glutamate. Excessive glutamate can activate the NMDA receptor, leading to massive depolarization of neuronal networks and bursts of action potentials. Magnesium may act to increase the seizure threshold by inhibiting NMDA receptors, thereby limiting the effect of glutamate.