Medical Knowledge

02/12/2023

30/11/2023

Liver function

30/11/2023

30/11/2023

Complete Blood Count (CBC) test is a common laboratory test that measures the number of red blood cells, white blood cells, and platelets in a sample of blood. Additionally, it can also include other parameters like:

Hemoglobin: A protein in red blood cells that carries oxygen to the body's tissues.

Hematocrit: The proportion of red blood cells to the total volume of blood.

Mean Corpuscular Volume (MCV): The average size of a red blood cell.

Mean Corpuscular Hemoglobin (MCH): The average amount of hemoglobin in a red blood cell.

Mean Corpuscular Hemoglobin Concentration (MCHC): The average concentration of hemoglobin in a red blood cell.

Red Cell Distribution Width (RDW): A measure of the size variation of red blood cells.

Platelet count: The number of platelets in a sample of blood.

White Blood Cell count: The number of white blood cells in a sample of blood.

Differential white cell count: The percentage of each type of white blood cell in the sample, such as neutrophils, lymphocytes, monocytes

30/11/2023

Mechanism of transport of co2 from tissue to the lungs through HCO3-

The transport of carbon dioxide (CO2) from tissues to the lungs occurs through a process known as bicarbonate (HCO3-) transport. This mechanism involves several steps and is crucial for maintaining the acid-base balance in the body. Let me explain the process in more detail:

Carbon Dioxide Production: In the tissues, cellular respiration generates carbon dioxide as a waste product. CO2 is produced as a result of metabolic processes within cells.

Diffusion of CO2: Carbon dioxide diffuses out of the cells into the interstitial fluid, where it dissolves in water to form carbonic acid (H2CO3). This process is facilitated by the high concentration of carbonic anhydrase enzyme present in the tissues.

Conversion to Bicarbonate: Carbonic acid (H2CO3) rapidly dissociates into a bicarbonate ion (HCO3-) and a hydrogen ion (H+). This reaction is catalyzed by carbonic anhydrase. The generated bicarbonate ion is highly soluble and can be transported easily.

Bicarbonate Transport: The bicarbonate ion (HCO3-) is then transported out of the tissues into the bloodstream. This occurs mainly through a process called the chloride shift. In this process, bicarbonate ions are exchanged with chloride ions (Cl-) across the red blood cell membrane. Bicarbonate ions leave the red blood cells, while chloride ions enter, maintaining electrical neutrality.

Plasma Transport: Bicarbonate ions are transported within the plasma, dissolved in the blood. They are carried through the venous system back to the heart and eventually reach the lungs.

Reverse Reaction: In the pulmonary capillaries within the lungs, bicarbonate ions diffuse into red blood cells. Simultaneously, chloride ions leave the red blood cells, reversing the chloride shift mechanism.

Formation of Carbonic Acid: Inside the red blood cells, bicarbonate ions combine with hydrogen ions (H+) to form carbonic acid (H2CO3). This reaction is catalyzed by carbonic anhydrase, which is abundant in red blood cells.

CO2 Elimination: Carbonic acid (H2CO3) then rapidly breaks down into carbon dioxide (CO2) and water (H2O). The CO2 can easily diffuse across the alveolar membrane into the air spaces of the lungs.

Exhalation: Finally, during expiration, the carbon dioxide (CO2) is expelled from the lungs through the respiratory system.

It is important to note that while the majority of CO2 is transported as bicarbonate ions, a small portion of it is also carried by hemoglobin in red blood cells or dissolved directly in plasma. These alternate pathways contribute to the overall transport of carbon dioxide in the blood.

30/11/2023

ALZLZHEIMER'S DISEASE

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by deterioration of multiple cognitive functions like learning, concentration, and memory.

The disease begins with mild loss of memory and ultimately leads to a decline in the ability to work independently and perform daily tasks.

According to the World Health Organization (WHO), over 50 million people have Alzheimer's disease or related dementia, and these numbers are expected to double in the next 20 years. Recent studies have determined a gender predilection with the disease; as per the latest research, women have a higher risk of being affected by Alzheimer's disease compared with men.

The chances of women developing Alzheimer's disease at the age of 65 are 1 in 5 as compared to 1 in 11 for men of the same age. Researchers are investigating the various biological, genetic variations which lead to a higher risk of Alzheimer's disease in women of any given age

AGE (A significant risk factor for developing Alzheimer's disease): Age is a significant risk factor for developing Alzheimer's disease. On average, women live four to five years longer than men.

However, longevity alone may not be able to explain increased Alzheimer's disease risk in women; factors like educational and occupational opportunities are equally responsible.

Less education in women is associated with increased risk of dementia, whereas increased cognitive activity in mid- or late-life is associ

30/11/2023

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What is adenomyosis?
✓Adenomyosis (pronounced “add-en-o-my-OH-sis”) is when tissue similar to the lining of your uterus (endometrium) starts to grow into the muscle wall of your uterus (myometrium). It causes your uterus to thicken and enlarge — sometimes, up to double or triple its usual size. Adenomyosis can cause painful periods, heavy or prolonged menstrual bleeding with clotting and abdominal/pelvic pain

What are the signs of adenomyosis?

About 1 in 3 people with adenomyosis don’t have signs or symptoms. Some people experience:

✓Painful menstrual cramps (dysmenorrhea).
✓Heavy menstrual bleeding (menorrhagia).
✓Abnormal menstruation.
✓Pelvic pain with or without severecramping.
✓Painful in*******se (dyspareunia).
✓Infertility.
✓Enlarged uterus.
✓Bloating or fullness in your belly (adenomyosis belly).

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