05/10/2022
Our article published in Royal Society Open Science (iF: 3.65).
Topical delivery is preferable over systemic delivery for cutaneous leishmaniasis, because of its easy administration, reduced systemic adverse effects and low cost. Nitazoxanide (NTZ) has broad-spectrum activity against various parasites and has the potential to avoid drug resistance developed by enzymatic mutations. NTZ oral formulation is associated with severe dyspepsia and stomach pain. In this study, we reported the fabrication of NTZ-TES topical formulation with significantly increased dermal pe*******on, reduced cytotoxicity and enhanced anti-leishmanial efficacy (figure 1). To the best of our knowledge, no such study has been reported so far. Moreover, the incorporation of NTZ in TEG for CL has not been reported earlier.
Topical delivery is preferable over systemic delivery for cutaneous leishmaniasis, because of its easy administration, reduced systemic adverse effects and low cost. Nitazoxanide (NTZ) has broad-spectrum activity against various parasites and has the ...
