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Gabriel-Ozil
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Oral route of administration is the slowest and it has a low bioavailability because it undergoes hepatic first pass metabolism in the gastrointestinal track or liver where it been metabolism.
Intravenous route of administration is the fastest and it has 100% bioavailability. It doesn't undergo hepatic first pass metabolism since the drug goes directly into the systemic circulation.
Bioavailability is defined as the amount of drug which reaches the site of physiological activity after administration.
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