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The packaging of DNA in eukaryotic cellsā¼ Because eukaryotes have large quantities of DNA to fit into a small space, the DNA needs to be tightly and efficiently packaged. Double-stranded DNA (1) is tightly coiled around histones to form nucleosomes (2 and 3). Nucleosomes and histones together form chromatosomes (4). The nucleosomes fold (5), loop (6) and compress (7) into chromatin. Tight coiling of the chromatin produces the chromatids of a chromosome (8).
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