تصميم الأدوية وبناؤها باستخدام النمذجة الجزيئية

نتشرف بحضوركم مناقشة رسالة الماجستير للطالبتين سالي مهداوي وصفاء التميمي , في قاعة الخوارزمي -كلية الصيدلة

تم بفضل الله نشر بحث جديد بالتعاون مع جامعة مؤتة والجامعة الأردنية بما يتعلق بتصنيع وتطوير أدوية جديدة تعالج السكرى باستهداف انزيم ألفا جلوكوسيديز.

Synthesis and structure–activity relationship studies of 1,2,4-triazole–benzoxazepine hybrids as α-glucosidase inhibitors: molecular docking and biological evaluation - Medicinal Chemistry Research A novel series of 1,2,4-triazole–benzoxazepine hybrid derivatives was designed, synthesized, and biologically evaluated as α-glucosidase inhibitors using an in vitro enzyme inhibition assay with acarbose as a reference standard. Several compounds demonstrated significant inhibitory activity, with...

بحث منشور يربط بين فيتامين د وبين الالتهابات والسرطانات , بحث مميز ونتيجة تسلط الضوء على أهمية فيتامين د للوقاية من السرطانات, البحث لمجموعة من الاساتذة بينهم د.حنين بشير - جامعة الزرقاء سابقا.

Vitamin D modulates the basal secretion of inflammatory cytokines in breast cancer cells: An in-vitro study Lina Elsalem, Lina Aldarayseh, Nosayba Al-Azzam, Haneen A. Basheer

Dimethylsulfoxide (DMSO) is a solvent that is used in preparing the samples for MTT assay and also as a cryoprotective to store cancerous cells at -80 °C or liquid nitrogen; however, it exerts cytotoxic effects on cancerous cells via a specific mechanism.

Dimethyl Sulfoxide Promotes the Multiple Functions of the Tumor Suppressor HLJ1 through Activator Protein-1 Activation in NSCLC Cells Background Dimethyl sulfoxide (DMSO) is an amphipathic molecule that displays a diversity of antitumor activities. Previous studies have demonstrated that DMSO can modulate AP-1 activity and lead to cell cycle arrest at the G1 phase. HLJ1 is a newly identified tumor and invasion suppressor that inhi...

تم بفضل الله قبول نشر بحث طالبة الماجستير أماني بعنوان " DESIGN, SYNTHESIS, AND EVALUATION OF NOVEL TYROSINASE INHIBITORS FOR SKIN DEPIGMENTATION" بمجلة
International Journal of Pharmaceutical Sciences, Scopus Q2 , مبارك أماني.

بفضل الله ومنته تم نشر بحث طالب الماجستير على الجبورى والمشتق من رسالة الماجستير في مجلة مصنفة عالميا ISI Q2 , مبارك يا على

Identification and biological assessment of amino benzoxazole derivatives as KDR inhibitors and potential anti-cancer agents - Journal of Computer-Aided Molecular Design A library of 39 amino-benzoxazole derivatives, selected from 57 benzoxazole compounds in the NCI database, was evaluated for their potential as KDR inhibitors using computational docking methods, including CDocker, LibDock, and AutoDock Vina. At a screening concentration of 100 µM, 11 compounds dem...

الحمد لله حمدا طيبا كثيرا مباركا فيه.

Novel 1,2,3-triazole-indole hybrid: synthesis, anti-cholinesterases, antioxidant activities, kinetic and molecular docking analysis - ScienceDirect

Novel 1,2,3-triazole-indole hybrid: synthesis, anti-cholinesterases, antioxidant activities, kinetic and molecular docking analysis A novel series of hybrid analogs incorporating an indole-bearing 1,2,3-triazole scaffold was synthesized and fully characterized. Their biological eva…

تم بفضل الله قبول البحث المشترك بعنوان " Novel 1,2,3-triazole-indole hybrid: synthesis, anti-cholinesterases, antioxidant activities, kinetic and molecular docking analysis
Journal of Molecular Structure " بالتعاون بين جامعة مؤتة والجامعة الأردنية مع جامعة الزرقاء والذي يتعلق بتصنيع مركبات جديدة كمضادات للأكسدة لغرض علاج مرض الألزهايمر

من المعلومات التي اثارت دهشتي تتعلق بمادة لايكوبين متوفرة بكثرة في البندورة (الطماطم) والتي حسب البحث المرفق قد يكون لها دور كبير في تحسين حالة مريض التوحد , المصدر مرفق.
Lycopene is a red carotenoid abundant in tomatoes, watermelon, grapefruit, papaya, apricot, and asparagus (Khaksar and Jahromi, 2016). It is one of the most potent antioxidants found in the human body, being the most potent among the different carotenoids (Imran et al., 2020) and having about 100 times antioxidant potency compared to vitamins E and C, 10 times that of α-tocopherol, and 125 times of glutathione (Kumar et al., 2017). In addition, it exhibits strong anti-inflammatory and cognitive-enhancing effects and has blood-brain barrier permeability; thus, it can diffuse into the brain, lowering the risk of neurodegenerative diseases (Erten, 2021). These properties make lycopene a promising neuroprotective agent capable of improving learning, memory, and potentially countering neurodegenerative processes (Varesi et al., 2023). Therefore, we hypothesize that lycopene might provide benefits for patients with autism.

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تم بفضل الله قبول النشر لبحث طالب الماجستير علي الجبورى وبعنوان "Identification and Biological Assessment of Amino Benzoxazole Derivatives as KDR Inhibitors and Potential Anti-Cancer Agents"
Journal of Computer-Aided Molecular Design (springer Q2)