07/08/2026
Most people assume NAD+ and NMN IVs are the same thing on a different clock. They’re not. NAD+ goes in and gets used almost immediately outside the cell.
NMN takes a different transporter — Slc12a8 — straight into the cell, where it converts to NAD+ from the inside. That’s the mechanism behind why one takes 3 hours and the other takes 30 minutes. Neither is ‘better’ in the abstract — it depends on what your case calls for.
The time difference isn’t arbitrary — it’s mechanism. NAD+ IV works extracellularly; NMN IV goes in through the Slc12a8 transporter and converts inside the cell (Grozio et al., Nature Metabolism, 2019). Comment “MECHANISM” and we’ll send you the full breakdown.
