Histamine Research Society Europe - HRSE

Don't forget to register and send in your abstracts! Early registration ends 30th June 2026!

Online registration and abstract submission for the upcoming joint meeting of the Histamine Research Society Europe (HRSE) and the Polish Society for Histamine Research, taking place on October 22 – 24, 2026 in Lodz, Poland.

https://www.ptbh.lodz.pl/en/home-eng/?lang=en

Interesting paper Interesting paper on the role of the H4 receptor in PD and MS; a nice collaboration between the Netherlands and China! This is an open access article.

Histamine H4 receptor in neuroinflammation: Dual roles in multiple sclerosis and Parkinson's disease.

Yan WJ, Yang YL, Yan W, Tian SY, Zi Y, Liu GJ, Yi ZA, Shao RX, Shi CY, Shan L, Zhuang QX. Neurobiol Dis. 2026 Apr 15:107400. doi: 10.1016/j.nbd.2026.107400

🚀 The Experimental Neurobiology Unit at the University of Antwerp ( https://www.uantwerpen.be/en/research-groups/experimental-neurobiology-unit/ is open to host MSCA Postdoctoral Fellowship 2026 applicants (deadline 09/09/2026). Interested in computational neurology, neuronal circuit physiology, neurochemistry and animal behaviour? Get in touch with them: https://lnkd.in/gesqhfVM

Experimental Neurobiology Unit (ENU) | Experimental Neurobiology Unit | University of Antwerp Research Mission Our research unit aims to unravel the neurobiological mechanisms supporting complex behaviours such as movement, cognition and emotion by means of both experimental models and human participants. A major focus in our unit is elucidating the cellular and circuit mechanisms that give....

Biogenic Amines and Related Biologically Active Compounds
with Histamine as a Key Amine JOINT CONFERENCE
of the Polish Society for Histamine Research and the Histamine Research Society Europe LODZ 22-24 OCTOBER 2026
The registration form and abstract forms are on https://www.ptbh.lodz.pl/?lang=en
Early registration fees end on 30th June!

Interesting review - Read the Review : https://go.nature.com/40Gj7UA

Nature Reviews Immunology: Ageing of the immune system is now realized to drive systemic ageing, and there is interest in targeting immune ageing in order to promote healthy ageing. Here, the authors detail how ageing affects different immune cell populations and discuss strategies to rejuvenate the immune system in order to extend healthspan.

Link to the Review in the comments.

Congratulations to our Polish colleagues for being awarded for a great paper on H3 receptors and pain perception. A nice collaboration with also the Holger Stark lab..

Katarzyna Popiołek-Barczyk
Postdoctoral Fellow at the Maj Institute of Pharmacology, Polish Academy of SciencesPostdoctoral Fellow at the Maj Institute of Pharmacology, Polish Academy of Sciences

I am pleased to inform that, based on the recommendation of the Committee of the Maj Institute of Pharmacology Scientific Council, our work was honored with the Director’s Award for the best scientific publication of 2025.

I would like to sincerely thank all co-authors of this publication for their invaluable contributions.

„Histamine H3 receptor blockade alleviates neuropathic pain through the regulation of glial cells activation”
Degutis M., Łażewska D., Barut J., Białoń M., Latacz G., Szczepańska K., Pietruś W., Werner T., Karcz T., Stark H., Kreiner G., Kieć-Kononowicz K., Starowicz K., Popiołek-Barczyk K.

LinkedIn This link will take you to a page that’s not on LinkedIn

Save the date! 2027 European Congress of Pharmacology in Frankfurt/Main, Germany, the HRSE is listed as partner society

There will be a new Special Issue of the International Journal of Molecular Sciences entitled “Neuroimmune Circuitry: Advances in Neuronal Regulation of Immunity.”
The bidirectional communication between the nervous and immune systems is now recognized as a fundamental regulatory axis in health and disease. Neuronal circuits within the hypothalamus, brainstem, and autonomic pathways modulate immune responses through defined molecular mechanisms, including neuropeptide signaling, neurotransmitter release, receptor-mediated pathways, and intracellular transcriptional regulation. Understanding how specific neuronal populations influence peripheral immune functions at the molecular level is essential for developing targeted therapeutic strategies in inflammatory, metabolic, infectious, and neurodegenerative disorders.
This Special Issue welcomes original research articles and reviews that focus on the molecular mechanisms underlying neuroimmune interactions. Topics of interest include neuronal regulation of cytokine production; neuropeptide- and GPCR-mediated immune modulation; transcriptional and epigenetic regulation of neuroimmune circuits; autonomic control of immune organs; neuroendocrine-immune crosstalk; single-cell and spatial transcriptomic approaches to neuroimmune interfaces; and molecular mechanisms linking stress, circadian rhythms, and immune regulation.
As IJMS is dedicated to molecular sciences, submissions should emphasize mechanistic insights and clearly define molecular pathways, rather than providing purely descriptive or clinical observations.

Dr. Roberto De Luca
Guest Editor

Publisher of Open Access Journals | MDPI MDPI is a publisher of peer-reviewed, open access journals since its establishment in 1996.

Read the paper here: https://go.nature.com/46a7AAe

Nature Reviews Drug Discovery: Neuroimmune interactions shape neurodegenerative disease progression. This Review examines how microglia interact signals from central and peripheral immune cells, outlines emerging therapeutic targets beyond core pathology, and discusses the growing need for immune-based biomarkers in Alzheimer’s disease and related disorders.

Link to the Review in the comments.

Simultaneous inhibition of cholinesterase and antagonism of histamine H3 receptors alleviates cognitive deficits and mitigates apoptosis in scopolamine-induced amnesia in mice

The Histamine Research Society Europe is pleased to highlight a new open-access publication in Frontiers in Behavioral Neuroscience from the group of Bassem Sadek and collaborators.

This study evaluates E100, a dual-active compound combining cholinesterase inhibition (ChEI) with histamine H3 receptor (H3R) antagonism, in a scopolamine-induced amnesia model in mice. The work addresses a key therapeutic challenge in Alzheimer’s disease (AD): the need for multi-target strategies that simultaneously modulate cholinergic and histaminergic dysfunction.

Dual targeting of cholinergic and histaminergic neurotransmission with E100 mitigates multiple pathological hallmarks of cognitive impairment, including inflammation, oxidative stress, and apoptosis. These findings reinforce the therapeutic rationale for dual ChEI/H3R antagonists as next-generation candidates for Alzheimer’s disease and related neurodegenerative conditions.

Read the full open-access article:
https://lnkd.in/eVuumS8w

The next in-person meeting of the HRSE will be held together with the 20th anniversary congress of the Polish Histamine Society. October 22-24, 2026 in Lodz, Poland.