Rainero Lab

Fantastic lab walk in the Peak District!

Welcome to the lab Fatmagul!! Joining the lab summer walk is a great way to start!

New addition to our lab's PhD Wall of Fame - Bian 🇸🇾

Congratulations to Bian on passing her PhD viva!!! Well deserved!

Our recent paper is now highlighted in :

www.growkudos.com

Our latest paper is out!!!
Novel kinase regulators of extracellular matrix internalisation identified by high-content screening modulate invasive carcinoma cell migration

Novel kinase regulators of extracellular matrix internalisation identified by high-content screening modulate invasive carcinoma cell migration This study identifies novel kinase regulators of extracellular matrix (ECM) internalization through a high-content screen, characterizing the α2β1 integrin/p38 signaling axis as required for the internalization integrin-bound ECM, which modulates cell migration and invasion in breast, ovarian and ...

Yay!!! Bian won a best poster prize 🏆 at the NECB2024!!!

Great presentation by Rachele at the 3rd year PGR symposium today + a fantastic 'express my PhD' artwork!!

New preprint from our lab by Sherry & Rachele: "The protease ADAMTS5 controls ovarian cancer cell invasion, downstream of Rab25"

The protease ADAMTS5 controls ovarian cancer cell invasion, downstream of Rab25 Ovarian cancer is the 3rd most common gynaecological malignancy worldwide, with a 5-year survival rate of less than 30% in the presence of metastasis. Metastatic progression is characterised by extensive remodelling of the extracellular matrix, primarily mediated by secreted matrix metalloproteinase...

Huge congratulations to Dr Sherry on brilliantly passing her PhD viva!!!

🎉 Excited to share our latest article published in :

The extracellular matrix supports breast cancer cell growth under amino acid starvation by promoting tyrosine catabolism Breast tumors are embedded in a collagen-rich extracellular matrix (ECM) network, where nutrients are scarce due to limited blood flow and elevated tumor growth. This study shows that invasive breast cancer cells use macropinocytosis-dependent uptake and lysosomal degradation of ECM to promote their...

New preprint from our lab, by Montse Llanses Martínez, Keqian Nan, , Rachele Bacchetti, Shengnan Yuan and : internalisation of integrin-bound modulates invasive carcinoma cell migration

Internalisation of integrin-bound extracellular matrix modulates invasive carcinoma cell migration The interaction between cancer cells and the extracellular matrix (ECM) plays a pivotal role in tumour progression. While the extracellular degradation of ECM proteins has been well characterised, ECM endocytosis and its impact on cancer cell progression, migration and metastasis is poorly understoo...