04/02/2026
🔥 The Child with an Unbreakable Fever 🔥
🧒 Paediatric ED Learning Case
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🧾 Case History
👦 4-year-old boy, previously well
🌡️ 6 days of high fever – not responding to paracetamol
😠 Irritable, poor oral intake
💊 Treated with oral antibiotics for tonsillitis → no improvement
🩺 Examination findings:
• 🔥 Temp 39.5°C
• ❤️ HR 140 bpm, alert but irritable
• 👄 Cracked red lips, strawberry tongue
• 👀 Bilateral non-purulent conjunctivitis
• 🌸 Maculopapular rash (trunk & limbs)
• ✋🤚 Swollen hands and feet
• 🧠 Cervical lymphadenopathy
🧪 Investigations:
• 📈 CRP 120 mg/L
• 📈 ESR 60 mm/hr
• 🔬 Neutrophilia
• 🩻 CXR & urine dip: normal
🚨 Persistent fever despite antibiotics → concern for systemic inflammatory disease
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❓ Question 1
What is the most likely diagnosis?
• Scarlet fever
• Kawasaki disease ✅
• Viral exanthem
• Toxic shock syndrome
✅ Answer: Kawasaki disease
✔️ Fever ≥5 days
✔️ ≥4 diagnostic features present:
1️⃣ Conjunctival injection
2️⃣ Oral mucosal changes
3️⃣ Rash
4️⃣ Extremity changes
5️⃣ Cervical lymphadenopathy
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❓ Question 2
What is the most serious potential complication?
• Pneumonia
• Coronary artery aneurysm ✅
• Glomerulonephritis
• Meningitis
✅ Answer: Coronary artery aneurysm
🫀 Major cause of long-term morbidity & mortality
📉 Preventable with early treatment
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❓ Question 3
What treatment most reduces the risk of coronary complications?
• High-dose corticosteroids
• Intravenous immunoglobulin (IVIG) ✅
• Broad-spectrum antibiotics
• Warfarin
✅ Answer: IVIG
💉 IVIG 2 g/kg (single dose) within 10 days of fever onset
⬇️ Dramatically reduces coronary artery aneurysm risk
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🧠 Kawasaki Disease – Explained Simply
🩺 A systemic vasculitis of childhood
👶 Typically affects children