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๐‡๐ฒ๐ฉ๐ž๐ซ๐ญ๐ž๐ง๐ฌ๐ข๐จ๐ง ๐ข๐ง ๐ฉ๐ซ๐ž๐ ๐ง๐š๐ง๐œ๐ฒ: NICE recommends labetalol as the preferred/first-line antihypertensive in pregnancy. The curr...
23/08/2026

๐‡๐ฒ๐ฉ๐ž๐ซ๐ญ๐ž๐ง๐ฌ๐ข๐จ๐ง ๐ข๐ง ๐ฉ๐ซ๐ž๐ ๐ง๐š๐ง๐œ๐ฒ:

NICE recommends labetalol as the preferred/first-line antihypertensive in pregnancy. The current NICE sequence is:

Labetalol โ†’ Nifedipine โ†’ Methyldopa

๐…๐จ๐ซ ๐œ๐ก๐ซ๐จ๐ง๐ข๐œ ๐ก๐ฒ๐ฉ๐ž๐ซ๐ญ๐ž๐ง๐ฌ๐ข๐จ๐ง ๐ข๐ง ๐ฉ๐ซ๐ž๐ ๐ง๐š๐ง๐œ๐ฒ, NICE says to consider labetalol; if unsuitable, consider nifedipine, then methyldopa.

๐…๐จ๐ซ ๐ฉ๐ซ๐ž-๐ž๐œ๐ฅ๐š๐ฆ๐ฉ๐ฌ๐ข๐š

NICE says to offer labetalol, followed by nifedipine and then methyldopa if needed.

๐…๐จ๐ซ ๐š๐œ๐ฎ๐ญ๐ž ๐ฌ๐ž๐ฏ๐ž๐ซ๐ž ๐ก๐ฒ๐ฉ๐ž๐ซ๐ญ๐ž๐ง๐ฌ๐ข๐จ๐ง ๐ข๐ง ๐ฉ๐ซ๐ž๐ ๐ง๐š๐ง๐œ๐ฒ /critical care, NICE lists labetalol (oral or IV), oral nifedipine, or IV hydralazine as immediate treatment options.

23/08/2026

Major Cardiology Updates Are Coming!

ESC Congress 2026 begins on August 28, bringing some of the most anticipated developments in cardiovascular medicine.

The congress is expected to feature four new ESC Clinical Practice Guidelines, alongside results from numerous late-breaking clinical trials.

Several of these updates could potentially influence everyday cardiovascular practice and future treatment recommendations.

๐Ÿซ€ โ€” important cardiology updates are coming in the next few days!

New ESC Heart Failure Guidelines โ€” potentially the biggest clinical update, with likely changes around contemporary foundational therapy, implementation, HFpEF/HFmrEF, devices, and newer evidence.

2. Cardiovascular Disease & Chronic Kidney Disease Guidelines โ€”

3. Cardiac Rehabilitation Guidelines โ€” updated recommendations on exercise, rehabilitation, secondary prevention and multidisciplinary care after cardiovascular disease/events.

4. 5th Universal Definition of Myocardial Infarction
โ€” It may refine how we distinguish myocardial injury from myocardial infarction

๐ˆ๐ง๐ฏ๐ž๐ซ๐ญ๐ž๐ ๐‚๐ก๐š๐ฆ๐ฉ๐š๐ ๐ง๐ž ๐๐จ๐ญ๐ญ๐ฅ๐ž ๐€๐ฉ๐ฉ๐ž๐š๐ซ๐š๐ง๐œ๐ž ๐จ๐Ÿ ๐ญ๐ก๐ž ๐‹๐จ๐ฐ๐ž๐ซ ๐‹๐ž๐ ๐‹๐ข๐ฉ๐จ๐๐ž๐ซ๐ฆ๐š๐ญ๐จ๐ฌ๐œ๐ฅ๐ž๐ซ๐จ๐ฌ๐ข๐ฌA chronic inflammatory and fibrosing complicati...
23/08/2026

๐ˆ๐ง๐ฏ๐ž๐ซ๐ญ๐ž๐ ๐‚๐ก๐š๐ฆ๐ฉ๐š๐ ๐ง๐ž ๐๐จ๐ญ๐ญ๐ฅ๐ž ๐€๐ฉ๐ฉ๐ž๐š๐ซ๐š๐ง๐œ๐ž ๐จ๐Ÿ ๐ญ๐ก๐ž ๐‹๐จ๐ฐ๐ž๐ซ ๐‹๐ž๐ 

๐‹๐ข๐ฉ๐จ๐๐ž๐ซ๐ฆ๐š๐ญ๐จ๐ฌ๐œ๐ฅ๐ž๐ซ๐จ๐ฌ๐ข๐ฌ

A chronic inflammatory and fibrosing complication of chronic venous insufficiency, characterized by painful induration, subcutaneous fibrosis, and hyperpigmentation of the lower legs, particularly around the gaiter region.

Progressive fibrosis and narrowing above the ankles can produce the classic โ€œinverted champagne bottleโ€ appearance.

๐‚๐ฅ๐š๐ฌ๐ฌ๐ข๐œ ๐š๐ฌ๐ฌ๐จ๐œ๐ข๐š๐ญ๐ข๐จ๐ง: ๐‚๐ก๐ซ๐จ๐ง๐ข๐œ ๐ฏ๐ž๐ง๐จ๐ฎ๐ฌ ๐ข๐ง๐ฌ๐ฎ๐Ÿ๐Ÿ๐ข๐œ๐ข๐ž๐ง๐œ๐ฒ

๐๐ž๐ฎ๐ซ๐จ๐ฅ๐จ๐ ๐ข๐œ๐š๐ฅ ๐‚๐š๐ฎ๐ฌ๐ž๐ฌ ๐จ๐Ÿ ๐๐ž๐ฌ ๐‚๐š๐ฏ๐ฎ๐ฌ๐ˆ๐ฆ๐ฉ๐จ๐ซ๐ญ๐š๐ง๐ญ ๐Ÿ๐จ๐ซ ๐Œ๐‘๐‚๐ ๐๐€๐‚๐„๐’Pes cavus should prompt consideration of an underlying neurologi...
23/08/2026

๐๐ž๐ฎ๐ซ๐จ๐ฅ๐จ๐ ๐ข๐œ๐š๐ฅ ๐‚๐š๐ฎ๐ฌ๐ž๐ฌ ๐จ๐Ÿ ๐๐ž๐ฌ ๐‚๐š๐ฏ๐ฎ๐ฌ

๐ˆ๐ฆ๐ฉ๐จ๐ซ๐ญ๐š๐ง๐ญ ๐Ÿ๐จ๐ซ ๐Œ๐‘๐‚๐ ๐๐€๐‚๐„๐’

Pes cavus should prompt consideration of an underlying neurological disorder, especially when bilateral.

๐‡๐ž๐ซ๐ž๐๐ข๐ญ๐š๐ซ๐ฒ ๐ฉ๐ž๐ซ๐ข๐ฉ๐ก๐ž๐ซ๐š๐ฅ ๐ง๐ž๐ฎ๐ซ๐จ๐ฉ๐š๐ญ๐ก๐ข๐ž๐ฌ

๐‚๐ก๐š๐ซ๐œ๐จ๐ญโ€“๐Œ๐š๐ซ๐ข๐žโ€“๐“๐จ๐จ๐ญ๐ก (๐‚๐Œ๐“) ๐๐ข๐ฌ๐ž๐š๐ฌ๐ž โ€” classic and most important association
Hereditary sensory and motor neuropathies

๐’๐ฉ๐ข๐ง๐š๐ฅ ๐œ๐จ๐ซ๐ / ๐ฌ๐ฉ๐ข๐ง๐š๐ฅ ๐๐ข๐ฌ๐จ๐ซ๐๐ž๐ซ๐ฌ

Friedreich ataxia
Spina bifida / spinal dysraphism
Tethered cord syndrome
Syringomyelia
Spinal cord tumour or other chronic spinal cord lesions

๐๐ž๐ฎ๐ซ๐จ๐ฆ๐ฎ๐ฌ๐œ๐ฎ๐ฅ๐š๐ซ ๐๐ข๐ฌ๐จ๐ซ๐๐ž๐ซ๐ฌ

Poliomyelitis / post-polio syndrome
Certain muscular dystrophies
Chronic peripheral neuropathies causing muscle imbalance

23/08/2026

A 28-year-old man is referred after a cardiac murmur is detected during a routine medical examination. He is asymptomatic and has no history of cyanosis. Examination reveals a normal pulse and a non-displaced apex beat. A prominent systolic thrill is palpable at the left lower sternal border, where a loud, harsh systolic murmur is heard. The intensity of the murmur remains unchanged with standing or the Valsalva manoeuvre.

Which cardiac lesion is most likely?

A. Mitral stenosis
B. Mitral regurgitation
C. Hypertrophic obstructive cardiomyopathy
D. Ventricular septal defect
E. Tricuspid regurgitation

23/08/2026

A 38-year-old man presents with exertional dyspnoea, intermittent chest discomfort and two episodes of presyncope. His father died suddenly at the age of 42 years. Examination reveals a forceful, bifid apical impulse and a systolic thrill at the left lower sternal border. A harsh systolic murmur becomes louder when he stands suddenly and during the Valsalva manoeuvre but becomes softer with squatting.

Which cardiac lesion is most likely?

A. Severe aortic stenosis
B. Mitral regurgitation
C. Hypertrophic obstructive cardiomyopathy
D. Ventricular septal defect
E. Aortic regurgitation

23/08/2026

A 60-year-old man presents with progressive fatigue, exertional dyspnoea and intermittent central chest discomfort. On examination, his pulse is low-volume The apex beat is displaced laterally and has a sustained, heaving character. A systolic thrill is palpable in the right second intercostal space and a harsh systolic murmur radiates to both carotid arteries. The second heart sound is soft.

Which cardiac lesion is most likely?

A. Aortic regurgitation
B. Mitral regurgitation
C. Severe aortic stenosis
D. Hypertrophic obstructive cardiomyopathy
E. Ventricular septal defect

23/08/2026

A 58-year-old man presents with a 3-month history of progressive fatigue, excessive thirst and frequent passage of large volumes of urine. He has also noticed unintentional weight loss and recurrent blurred vision. Examination shows dry mucous membranes, reduced skin turgor and cool peripheries. His urine specific gravity is 1.023.

Which of the following is the most likely underlying cause of his polyuria?

A. Central diabetes insipidus
B. Nephrogenic diabetes insipidus
C. Primary polydipsia
D. Glucose-induced osmotic diuresis
E. Defective renal concentrating ability

Complications and Adverse Effects of BisphosphonatesGastrointestinal complicationsDyspepsiaEsophagitis and esophageal ul...
23/08/2026

Complications and Adverse Effects of Bisphosphonates

Gastrointestinal complications

Dyspepsia
Esophagitis and esophageal ulceration
Gastritis or gastric ulceration

Musculoskeletal complications
Atypical femoral fracture
Medication-related osteonecrosis of the jaw

Metabolic complications

Hypocalcaemia
Hypophosphataemia
Secondary hyperparathyroidism

Acute-phase reaction
Common after the first intravenous dose, especially zoledronic acid:

Fever
Chills
Fatigue
Myalgia and arthralgia
Influenza-like symptoms

Ocular inflammation

Conjunctivitis
Episcleritis
Scleritis
Anterior uveitis
Orbital inflammation, rarely

Other rare complications

Severe cutaneous reactions, including Stevensโ€“Johnson syndrome
Hypersensitivity or anaphylaxis
External auditory-canal osteonecrosis

23/08/2026

A 55-year-old woman with diabetes is admitted with high-grade fever, headache, myalgia, nausea and progressive jaundice shortly after returning from Brazil. She did not receive the recommended travel vaccinations. Laboratory investigations reveal severe thrombocytopenia, elevated aminotransferases and hyperbilirubinaemia.

Which infection is the most likely diagnosis?

A. Dengue fever
B. Yellow fever
C. Leptospirosis
D. Falciparum malaria
E. Hepatitis A

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