Egyptian stem cell researchers

15/07/2026

خالص التهاني الى الاستاذ الدكتور محمد صلاح
أستاذ علم الخلايا والأنسجة بكلية العلوم جامعة الفيوم
حيث تم بحمدالله نشر بحثه الثاني بمجلة Nature
https://www.nature.com/articles/s41586-026-10737-8
"Non-genotoxic transplantation and in vivo selection through epitope editing"
في إنجاز علمي يفتح آفاقًا جديدة في مجال الطب التجديدي والعلاج الجيني، نشرنا مؤخرًا بمجلة Nature دراسةً تستعرض استراتيجية مبتكرة لتجاوز أخطر عقبة تواجه زراعة نخاع العظم، ألا وهي الحاجة إلى العلاجات الكيميائية والإشعاعية السامة التي تُستخدم تقليديًا لتهيئة المريض قبل الزرع، والتي تتسبب في آثار جانبية مدمرة كالعقم واضطرابات المناعة وزيادة خطر الأورام الثانوية. وتعتمد طريقتنا الجديدة، التي أسميناها "الزرع غير السام للجينات والانتقاء الحيوي عبر تحرير موضع الارتباط المناعي"، على استخدام تقنيات التحرير الجيني الدقيق من قبيل Base Editing وPrime Editing لإدخال تغيير جيني متناهي الصغر - لا يتجاوز حمضًا أمينيًا واحدًا - في بروتين KIT الموجود على سطح الخلايا الجذعية المزروعة، بحيث يصبح هذا البروتين غير قابل للارتباط بالأجسام المضادة العلاجية دون أن يفقد وظيفته الحيوية، وهو ما يمنح هذه الخلايا "تمويهًا" يجعلها محصنة ضد أي هجوم مناعي مُخطط. وفي المقابل، يُستخدَم الجسم المضاد نفسه لاستهداف الخلايا الجذعية المريضة أو القديمة في نخاع العظم وإزالتها بشكل انتقائي، بينما تبقى الخلايا الجديدة المُعدَّلة محمية، وهنا يكمن الابتكار الأهم، حيث أن استمرار إعطاء الجسم المضاد بعد الزرع يُحدث انتقاءً حيويًا تدريجيًا داخل الجسم، إذ يستمر في القضاء على أي خلايا غير محمية متبقية، مما يتيح للخلايا الجذعية المُحرَّرة أن تزدهر وتستعمر نخاع العظم وتصل إلى النسبة العلاجية المطلوبة لتحقيق الشفاء. بالإضافة إلى ذلك، تم دمج هذه التقنية مع تعطيل محفز جين BCL11A لتحفيز إنتاج الهيموغلوبين الجنيني، مما يجعل هذه الاستراتيجية واعدة بشكل خاص لعلاج أمراض الدم الوراثية الشائعة كالأنيميا المنجلية والثلاسيميا، حيث يُمكن الآن للمرضى - حتى الأكثر هشاشة أو ممن لا يتحملون العلاجات التقليدية - أن يتلقوا علاجًا منقذًا للحياة دون التعرض لمخاطر التثبيط المناعي المزمن أو الأورام الثانوية، وهو ما يمثل نقلة نوعية في مفهوم زراعة نخاع العظم والعلاج الجيني ويضع حجر الأساس لعصر جديد من العلاجات الآمنة والفعالة في آن واحد.

أ.د محمد صلاح
كلية العلوم جامعة الفيوم

Epitope editing of KIT enables antibody-based, non-genotoxic conditioning that selectively enriches therapeutic BCL11A-edited haematopoietic stem/progenitor cells, supports durable engraftment, preserves clonal diversity and enhances induction of fetal haemoglobin, a therapeutic approach for conditi...

10/04/2026

Molecular Biologist (On-site | Amman)

GenoDiscovery (Amman, Jordan) is seeking a highly competent Molecular Biologist to join its molecular biology laboratory and research services team.

This position is intended for experienced molecular biologists who can work beyond routine protocols and actively contribute to advanced laboratory workflows, method optimization, and complex testing projects.

Mandatory Requirements:
• BSc or MSc in Biotechnology or Genetic Engineering ONLY
(MSc holders are highly welcomed)
• Minimum 1 year of proven experience in a molecular biology research laboratory
• Strong hands-on expertise in:
• DNA/RNA extraction from multiple biological sources
• Conventional PCR & real-time PCR (qPCR)
• Genotyping and gene expression analysis
• NGS library preparation, sequencing workflows, and data interpretation
• Excellent command of aseptic techniques and operation of advanced laboratory instruments
• Proven experience in SOP writing and scientific documentation
• Ability to troubleshoot, optimize protocols, and deliver accurate results under strict deadlines
• High level of precision, accountability, and analytical thinking
• Amman residents only
• Ready for full-time, on-site work

🚫 Hard Filter:
Candidates limited to routine testing only, without experience in troubleshooting, protocol optimization, or independent data interpretation, will not be considered.

📌 Apply only if you meet all the above requirements
📧 Send CV to: [email protected] (ONLY)

15/02/2026

Apoptosis Vs Necrosis
🧬 1. Definition

Apoptosis is a planned and controlled process of cell death. The cell actively participates in its own destruction in an orderly way.
Necrosis is an accidental and uncontrolled form of cell death that happens when a cell is severely damaged.

🌿 2. Nature (Physiological vs Pathological)

Apoptosis is a normal and useful biological process. It helps shape organs, remove damaged cells, and maintain tissue balance.
Necrosis is always abnormal and harmful. It occurs due to disease, injury, or severe stress on cells.

⚠️ 3. Cause

Apoptosis happens due to internal genetic signals or controlled external signals (like DNA damage, aging cells, or development).
Necrosis occurs due to external injury such as trauma, infection, toxins, burns, or lack of oxygen (ischemia).

👥 4. Cells Affected

Apoptosis usually affects individual cells in a tissue without disturbing neighboring cells.
Necrosis often affects large groups of cells in a region because injury usually damages many cells at once.

📉 5. Cell Size

Apoptosis: The cell shrinks as it breaks down neatly.
Necrosis: The cell swells because it loses control of water and ion balance.

🧱 6. Cell Membrane

Apoptosis: The cell membrane stays intact and forms small sealed fragments called apoptotic bodies.
Necrosis: The cell membrane breaks open (ruptures), spilling cell contents outside.

🧪 7. Cell Contents

Apoptosis: Cell contents are safely packaged and removed by immune cells (phagocytes).
Necrosis: Cell contents leak into surrounding tissue, damaging nearby cells.

🔥 8. Inflammation

Apoptosis: No inflammation occurs because cell contents do not leak.
Necrosis: Inflammation occurs because leaked cell materials trigger immune reactions.

⚡ 9. Energy Requirement

Apoptosis requires energy (ATP) because it is an active, controlled process.
Necrosis does not require energy — it happens when the cell loses energy and control.

🧩 10. Mechanism

Apoptosis is regulated by special enzymes called caspases that systematically dismantle the cell.
Necrosis occurs when cell structures break down uncontrollably due to damage.

🌱 11. Effect on the Body

Apoptosis is beneficial — it removes unwanted, damaged, or infected cells and supports healthy development.
Necrosis is harmful — it damages tissue and may worsen disease.

🩺 12. Example

Apoptosis: Removal of webbed tissue between fetal fingers, elimination of old immune cells.
Necrosis: Tissue death after a heart attack, severe burns, or bacterial infection.

24/12/2025

Histology is still at the cornerstone of clinical pathology, underlying the power of tissue morphology in discriminating between different disease entities, predicting patient outcomes, and guiding treatment decisions

16/10/2025

https://www.linkedin.com/redir/redirect/?url=https%3A%2F%2Fwww%2Ecam%2Eac%2Euk%2Fresearch%2Fnews%2Fnobel-laureate-professor-sir-john-gurdon-dies-aged-92&urlhash=yAB3&isSdui=true

It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the Gurdon Institute.

05/10/2025

PhD Student in the Stem Cells and Cancer Lab - Prof. Arianna Baggiolini

Institute of Oncology Research (IOR)

IOR - Institute of Oncology Research in Bellinzona, Switzerland

Deadline: November 15th, 2025

Details 👇

24/09/2025

Apply early not too late

26/07/2025

In a major breakthrough, Japanese scientists at Mie University used CRISPR to remove the extra chromosome 21 from lab-grown cells of individuals with Down syndrome. The edited cells showed improved function and normalized gene expression. Though not yet ready for clinical use, the study marks a significant step toward future genetic therapies.

10/07/2025

Jove

26/06/2025

The mouse (Mus musculus) is considered the best superstar animal model in biomedical research for several compelling reasons, spanning genetics, physiology, practical utility, and translational relevance.

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🧬 1. Genetic Similarity to Humans

Mice share about 95–98% of their genes with humans.

Many genes involved in disease, development, and physiology are highly conserved.

This makes them ideal for modeling human diseases, including cancer, diabetes, neurodegenerative diseases, and autoimmune disorders.

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🧪 2. Ease of Genetic Manipulation

Mice were the first mammals to be genetically engineered.

Availability of transgenic, knockout, and CRISPR/Cas9-modified strains allows researchers to study specific gene functions.

The International Knockout Mouse Consortium has created thousands of gene-specific models.

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🐁 3. Short Reproductive Cycle and Lifespan

Mice reproduce quickly: gestation ~19–21 days, sexual maturity at 6–8 weeks.

A short lifespan (~2 years) allows for aging studies and observing disease progression over a full life course in a short time.

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💉 4. Well-Characterized Immune System

Extensive knowledge of the mouse immune system makes it ideal for studying:

Immunotherapy

Vaccine development

Autoimmune and inflammatory diseases

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🧠 5. Behavioral and Neurological Research

Mice are widely used in neuroscience and psychology due to their well-understood brain structure and behavior.

Common in studies on learning, memory, anxiety, depression, and neurodegeneration (e.g., Alzheimer’s).

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🧾 6. Vast Research Infrastructure and Resources

A massive base of published literature, commercial vendors, and research tools supports mouse-based research.

Organizations like The Jackson Laboratory offer an extensive library of genetically defined mouse strains.

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🔬 7. Cost-Effective and Practical

Mice are small, easy to house, and relatively inexpensive to maintain.

Require less compound/material for drug testing compared to larger animals.

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🔄 8. Translational Relevance

Many preclinical trials begin in mouse models.

Though not perfect, results in mice often provide crucial insights that guide clinical research in humans.