National Center for Nanoscience and Technology

We invite interested students to join the UCAS Admissions Briefing 2025 on December 17-19, 2024. Please join National Center for Nanoscience and Technology at 17:55 Beijing time at December 17, 2024. Thank you!

Recently, the research team led by SHI Xinghua from the National Center for Nanoscience and Technology (NCNST) of the Chinese Academy of Sciences (CAS), in collaboration with GAO Huajian's team from Tsinghua University, developed a new reinforcement learning-based enhanced sampling method called Adaptive Collective Variables Generator (Adaptive CVgen). This method has been successfully applied to study protein folding and the synthesis of fullerene (C60). The study was published in the Proceedings of the National Academy of Sciences (PNAS).

Adaptive CVgen: Leveraging reinforcement learning for advanced sampling in protein folding and chemical reactions | PNAS Enhanced sampling techniques have traditionally encountered two significant challenges: identifying suitable reaction coordinates and addressing th...

Nanomaterials/nanomedicines will absorb various biomolecules including proteins, nucleic acids and metabolites to form a biocorona coating once entering biological or environmental systems. The nanomaterial biocorona endows nanomaterials with new biological identity and influences their biological behaviors and fates including cellular uptake, immune response, biodistribution, elimination, etc. The analysis of nanomaterial biocoronas benefits in-depth understanding of the pharmacology and toxicology of nanomaterials, which is crucial to guide the safe-by-design of nanostructures and the clinic translation of nanomedicines. However, the high complexity of biological systems and the dynamic interactions between biomolecules pose great challenges for the analysis and characterization of nanomaterial biocoronas.

Researchers led by Prof. CHEN Chunying from the National Center for Nanoscience and Technology (NCNST) of the Chinese Academy of Sciences (CAS) and Prof. Iseult Lynch from University of Birmingham recently have made important progress in the characterization methodology of nanomaterials biocoronas. The study was published in Nature Protocols.

Analysis of nanomaterial biocoronas in biological and environmental surroundings - Nature Protocols Engineered and anthropogenic nanoscale materials in the environment acquire a coating of biomolecules (biocorona) that modulates their properties, uptake and biodistribution. This protocol streamlines biocorona analysis to support the development of safe and sustainable nanotechnology.

🎓✨ Celebrating a Historic Graduation Ceremony at the National Center for Nanoscience and Technology! ✨🎓
National Center for Nanoscience and Technology marking the highest number of graduates ever in the summer of 2024.
Director Tang Zhiyong of the center expressed his blessing to all graduates. He pointed out that the graduates are in the golden period of national development and shoulder an important mission. He encouraged everyone to contribute to improving their country's scientific and technological innovation capabilities and achieving scientific and technological self-reliance.
Director Tang also expressed his deep concern for the future lives of the graduates, stressing the importance of balancing career success with family and health to achieve a harmonious work-life balance and enjoy a happy life.

Congratulations to all our graduates! May your future be bright, balanced, and full of achievements. 🌟🌍🔬

In a study published in Proceedings of the National Academy of Sciences of the United States of America (PNAS), Prof. GAO Yurui’s group from the National Center for Nanoscience and Technology (NCNST) of the Chinese Academy of Sciences (CAS), in collaboration with Prof. ZENG Xiaocheng from City University of Hong Kong and Prof. FRANCISCO Joseph S. from the University of Pennsylvania, have now employed photolithography techniques and subsequent processing to fabricate a class of structured surfaces featuring concentric closed-loop microwalls/microchannels. This approach allows for precise control of microdroplets with wide range of CAs, and high shape and pattern tunability.

Topological wetting states of microdroplets on closed-loop structured surfaces: Breakdown of the Gibbs equation at the microscale | Proceedings of the National Academy of Sciences Microdroplets are a class of soft matter that has been extensively employed for chemical, biochemical, and industrial applications. However, fabric...

Recently, Kamran Amin, a PhD graduate from the National Center for Nanoscience, presented a wonderful report titled "Researcher's Toolkit: Essential Resources for Academic Excellence" to students as the keynote speaker.

This academic presentation was focused on enhancing essential scientific research skills and provides a valuable learning opportunity for international students at the center. The attending students expressed that they have gained a lot and look forward to the center hosting more similar academic activities in the future, injecting new vitality and inspiration into scientific research work.

The study, led by Prof. LIU Xinfeng from the National Center for Nanoscience and Technology (NCNST) of the Chinese Academy of Sciences (CAS), recently reported an enhancement in exciton mobility in a two-dimensional Ruddlesden-Popper perovskite. The findings have been published in Nature Communications.
Prof. LIU’s group at the National Center for Nanoscience and Technology, in collaboration with Prof. Wu Bo at South China Normal University and Associate Prof. Zhang Qing at Peking University, has successfully achieved a boosted exciton mobility approaching the Mott-Ioffe-Regel Limit (MIR) in 2D RPP by anchoring the soft butyl ammonium cation with a polymethyl methacrylate (PMMA) network at the surface.

Boosting exciton mobility approaching Mott-Ioffe-Regel limit in Ruddlesden−Popper perovskites by anchoring the organic cation - Nature Communications Exciton transport in 2D Ruddlesden−Popper perovskite plays a key role for their optoelectronic performance. Here, authors significantly enhance free exciton mobilities in exfoliated thin flakes by anchoring butyl ammonium cation with polymethyl methacrylate, which also improves lattice rigidity.

Chinese New Year Ceremony organized by the National Center for Nanoscience and Technology! 🎉 The performances were absolutely wonderful, showcasing the rich cultural diversity and talent within our community. Huge thanks to the organizers for creating such a memorable celebration!

Nature Protocols published an original methodology paper of Prof. CHEN Chunying’s group from the National Center for Nanoscience and Technology (NCNST) of the Chinese Academy of Sciences (CAS), entitled In situ label-free X-ray imaging for visualizing the localization of nanomedicines and subcellular architecture in intact single cells.

In situ label-free X-ray imaging for visualizing the localization of nanomedicines and subcellular architecture in intact single cells - Nature Protocols An X-ray microscopy approach for 2D or 3D label-free visualization of the intracellular distribution of nanomedicines and the morphology of organelles in primary blood cells, macrophages, dendritic cells, monocytes and cancer cells.

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After the outbreak of the novel coronavirus in 2020, vaccines, antibodies (Abs), small molecule drugs and other interventions need to be researched, and such a rapid development is partly due to the accumulation of scientific research in severe acute respiratory syndrome virus (SARS virus, SARS-CoV-1), MERS-CoV and other coronaviruses that cause human disease. SARS-CoV-1 and SARS-CoV-2 belong to the Sarbecovirus of the Beta coronavirus, and have similarities in the structure and function of the surface membrane protein Spike, and both invade cells mediated by the interaction between the viral spike (S) glycoprotein and the ACE2 receptor on the host cell surface. However, due to the limitations of technology and methodology, there exist many questions in the characteristics of SARS-CoV-1 antibody response and the relation to SARS-CoV-2 antibody response.

Professor ZHANG Linqi's team from School of Medicine, Tsinghua University, Professor LI Taisheng's team from Peking Union Medical College Hospital, and Professor YANG Yuhe's team from National Center for Nanoscience and Technology, published online in Immunity under the title "Dissecting the intricacies of human antibody responses to SARS-CoV-1 and SARS-CoV-2 infection". The antibody response of SARS-CoV-1 convalescents was analyzed from the aspects of polyclonal antibodies (pAbs) and monoclonal antibodies (mAbs), and was compared the duration, classification and properties of RBD Abs.

Dissecting the intricacies of human antibody responses to SARS-CoV-1 and SARS-CoV-2 infection The 2003 severe acute respiratory syndrome coronavirus (SARS-CoV-1) causes more severe disease than SARS-CoV-2, which is responsible for COVID-19. How…