Computational Biology Institute

Established in 2012 on The George Washington University's Virginia Science and Technology Campus in The Computational Biology Institute (CBI) at the George Washington University (GW) is an interdisciplinary effort building on GW’s strengths in life sciences and computational science, in addition to the wealth of research centers in the Washington, DC-area.

Operating as usual

Biological Science Laboratory Technician 02/12/2018

Biological Science Laboratory Technician

New posting at Smithsonian Institution: Biological Science Laboratory Technician (Analytical Biology)

https://www.usajobs.gov/GetJob/ViewDetails/490597500

Biological Science Laboratory Technician This position will provide technical support for molecular genetics research and collections in the Laboratories of Analytical Biology (L.A.B.), National Museum of Natural History (NMNH), Smithsonian Institution, Washington, DC (primary duty station is at the Natural History Museum in DC but some wo...

Phylogeography reveals unexpectedly low genetic diversity in a widely distributed species: the case of the freshwater crab Aegla platensis (Decapoda: Anomura) | Biological Journal of the Linnean Society | Oxford Academic 02/05/2018

Phylogeography reveals unexpectedly low genetic diversity in a widely distributed species: the case of the freshwater crab Aegla platensis (Decapoda: Anomura) | Biological Journal of the Linnean Society | Oxford Academic

Professor Keith Crandall, Director of the Computational Biology Institute, and Assistant Professor Marcos Perez-Losada co-authored an article published in the Biological Journal of the Linnean Society, titled "Phylogeography reveals unexpectedly low genetic diversity in a widely distributed species: the case of the freshwater crab Aegla platensis (Decapoda: Anomura)", which was published on February 3rd, 2018. The article is the result of an investigation into the genetic diversity of aeglids, which usually have a narrow phylogeographical distribution. Aegla platensis, on the other hand, is widely distributed geographically, but of 17 populations examined from Argentina and Brazil, only one might represent a new species, while the others belong to a single species, on the basis of three molecular markers.

Phylogeography reveals unexpectedly low genetic diversity in a widely distributed species: the case of the freshwater crab Aegla platensis (Decapoda: Anomura) | Biological Journal of the Linnean Society | Oxford Academic Habitat and taxon-specific properties could affect the propensity for cryptic species to be formed. For example, anomurans of the genus Aegla possess characteristics that suggest the existence of cryptic diversity. The widely distributed species Aegla platensis, besides having been considered paraph...

Research Scientist, NGS Core 02/02/2018

Research Scientist, NGS Core

The Computational Biology Institute is hiring a Research Scientist for our Next-Gen Sequencing Core!

Research Scientist, NGS Core The Computational Biology Institute in the Milken Institute School of Public Health at The George Washington University is seeking a highly-motivated candidate for a position as a Research Scientist with the Next-Gen Sequencing (NGS) Core. A successful applicant will be ready and willing to assist w...

Postdoctoral Scientist 02/01/2018

Postdoctoral Scientist

The Computational Biology Institute is hiring a postdoc! https://www.gwu.jobs/postings/49199 Come work with us!

Postdoctoral Scientist The Computational Biology Institute in George Washington University's Milken Institute School of Public Health is seeking a highly motivated Postdoctoral Scientist (PDS). The work performed by the PDS will contribute to our diverse research program devoted to the investigation of: i) the role of mic...

Phylogenetic analysis of apicomplexan parasites infecting commercially valuable species from the North-East Atlantic reveals high levels of diversity and insights into the evolution of the group 01/30/2018

Phylogenetic analysis of apicomplexan parasites infecting commercially valuable species from the North-East Atlantic reveals high levels of diversity and insights into the evolution of the group

Assistant Professor Marcos Perez-Losada co-authored an article published in Parasites and Vectors on January 25th, 2018. The article, titled "Phylogenetic analysis of apicomplexan parasites infecting commercially valuable species from the North-East Atlantic reveals high levels of diversity and insights into the evolution of the group," deals with the apicomplexa, organisms from aquatic environments which are understudied relative to their terrestrial counterparts. The seminal work assessing the phylogenetic relations of fish-infecting lineages is mostly based on freshwater hosts. The taxonomic uncertainty of some apicomplexan groups, such as the coccidia, is high and many genera were recently shown to be paraphyletic, questioning the value of strict morphological and ecological traits for parasite classification. For this article, the authors surveyed the genetic diversity of the Apicomplexa in several commercially valuable vertebrates from the North-East Atlantic, including farmed fish.

Phylogenetic analysis of apicomplexan parasites infecting commercially valuable species from the North-East Atlantic reveals high levels of diversity and insights into the evolution of the group The Apicomplexa from aquatic environments are understudied relative to their terrestrial counterparts, and the seminal work assessing the phylogenetic relations of fish-infecting lineages is mostly based on freshwater hosts. The taxonomic uncertainty of some apicomplexan groups, such as the coccidia...

Sequencing the world 01/24/2018

Sequencing the world

Professor Keith Crandall, Director of the Computational Biology Institute, was cited in a recent article in The Economist on January 23rd, 2018, "Sequencing the world," as one of the 23 participants in a research project to "gather DNA sequences from specimens of all complex life on Earth" as part of the Earth BioGenome Project. Dr. Crandall's work on the EBP is at the heart of the work being done by many members of the Computational Biology Institute at The George Washington University. Dr. Crandall participated in an interview with journalists from The Economist at the Smithsonian, leading to the publication of the article.

Sequencing the world How to map the DNA of all known plants and animal species on Earth

01/17/2018
10/23/2017
10/20/2017

Marcos Perez-Losada and Gustav Nino to Receive NIH-R21

Assistant Professor Marcos Perez-Losada is co-investigator, along with Gustav Nino as the primary investigator, in an exploratory/developmental research grant titled: “Exosomal miR-155 Regulates Airway Epithelial Immune Responses in Infants with Rhinovirus Infection.” The grant aims to establish the immunomodulatory role of miR-155 in airway epithelial cells of infants in an effort to translate basic and clinical research into novel therapeutic strategies to improve health outcomes in young children. Perez-Losada will provide bioinformatics data analysis for the project, with the goal of characterizing the exosomal miR-155 secretory response during in-vivo RV infection and determine its association with airway immune responses and clinical disease.

10/17/2017

publichealth.gwu.edu

CBI: New Analysis Characterizes HIV Epidemic in Washington, DC https://publichealth.gwu.edu/content/new-analysis-characterizes-hiv-epidemic-washington-dc

publichealth.gwu.edu

10/17/2017

Hackital - GW's Hackathon

Hackital - a Hackathon in the Capital! http://mailchi.mp/3aff6a31bbb7/hackital-gw?e=bd8fa8963c

Hackital - GW's Hackathon

10/16/2017

Today at 12pm:

Photos from Computational Biology Institute's post 09/13/2017

The CBI was out at the Nationals game last night!

Assistant or Associate Professor at George Washington University 09/07/2017

Assistant or Associate Professor at George Washington University

Please share: The Computational Biology Institute and the Department of Epidemiology and Biostatistics at GWU are hiring 1 to 2 assistant/associate professors!

Assistant or Associate Professor at George Washington University Assistant or Associate Professor at George Washington University

Overexpressed somatic alleles are enriched in functional elements in Breast Cancer 08/23/2017

Overexpressed somatic alleles are enriched in functional elements in Breast Cancer

Overexpressed somatic alleles are enriched in functional elements in Breast Cancer Asymmetric allele content in the transcriptome can be indicative of functional and selective features of the underlying genetic variants. Yet, imbalanced alleles, especially from diploid genome regions, are poorly explored in cancer. Here we systematically quantify and integrate the variant allele f...

08/18/2017

Crandall and Stern Published in Evolution | Computational Biology Institute | The George Washington University

Keith Crandall and CBI student David Stern were published in Evolution! Their article suggests caves may not be such "evolutionary dead ends" after all:

Crandall and Stern Published in Evolution | Computational Biology Institute | The George Washington University Professor Keith Crandall co-authored "Phylogenetic evidence from freshwater crayfishes that cave adaptation is not an evolutionary dead-end" with Computational Biology Institute student David Stern, which was published in Evolution on August 14th, 2017.

Computational Biology Institute Updates Classification for Freshwater Crayfishes | Milken Institute SPH 08/09/2017

Computational Biology Institute Updates Classification for Freshwater Crayfishes | Milken Institute SPH

So cool! Keith Crandall published a single, comprehensive taxonomic summary of all the recognized species of crayfish of the world in the Journal of Crustacean Biology!

Computational Biology Institute Updates Classification for Freshwater Crayfishes | Milken Institute SPH A new paper published in the Journal of Crustacean Biology provides an updated classification system that includes all the known crayfishes worldwide.

07/31/2017

6th Annual Georgetown Biomedical Informatics Symposium | Computational Biology Institute | The George Washington University

Register now for the ICBI Innovation Center for Biomedical Informatics- Georgetown University 6th Annual Biomedical Informatics Symposium!

6th Annual Georgetown Biomedical Informatics Symposium | Computational Biology Institute | The George Washington University The Innovation Center for Biomedical Informatics at Georgetown University will be hosting the 6th Annual Georgetown Biomedical Informatics Symposium on Friday, October 27th, 2017, from 8am to 6pm. You can register now at icbi.georgetown.edu/symposium. The keynote speaker will be Patricia Flatley Bre...

DC I-Corps helps science-based startups find their market - Technical.ly DC 07/26/2017

DC I-Corps helps science-based startups find their market - Technical.ly DC

Keith Crandall/GW's spin-off company, Aperiomics, is attracting attention!

DC I-Corps helps science-based startups find their market - Technical.ly DC The NSF-funded program puts tech ideas through a stress test with a seven-week bootcamp and intensive customer research.

07/12/2017

Job Opportunities in Computational Biology | Computational Biology Institute | The George Washington University

New job posting! Researcher/Software Developer GGBN 2020, check it out!

Job Opportunities in Computational Biology | Computational Biology Institute | The George Washington University ***POSTED 6/20/17*** Position type: Postdoctoral Position at the NIHPosition Title: Cancer Genomics A Postdoctoral position is available in the laboratory of Dr. Daphne W. Bell, within the Cancer Genetics and Comparative Genomics Branch of the National Human Genome Research Institute, at NIH.

07/10/2017

Marcos Perez-Losada Published in Zoological Journal of the Linnean Society | Computational Biology Institute | The George Washington University

And Marcos Perez-Losada was published twice in the same issue!

Marcos Perez-Losada Published in Zoological Journal of the Linnean Society | Computational Biology Institute | The George Washington University Assistant Research Professor Marcos Perez-Losada co-authored the study, "Multigene phylogeny reveals two new isolated and relic earthworm genera (Oligochaeta: Lumbricidae)," which was published in the Zoological Journal of the Linnean Society on July 3rd, 2017. Phylogenetic analysis has revealed man...

07/10/2017

Keith Crandall and Marcos Perez-Losada Published in Zoological Journal of the Linnean Society | Computational Biology Institute | The George Washington University

Keith Crandall and Marcos Perez-Losada were published in the Zoological Journal of the Linnean Society!

Keith Crandall and Marcos Perez-Losada Published in Zoological Journal of the Linnean Society | Computational Biology Institute | The George Washington University Professor Keith Crandall and Assistant Research Professor Marcos Perez-Losada co-authored the study, "Looks can be deceiving: species delimitation reveals hidden diversity in the freshwater crab Aegla longirostri (Decapoda: Anomura)," which was published in the Zoological Journal of the Linnean Soci...

06/21/2017

Student Opportunities | Computational Biology Institute | The George Washington University

Great internship opportunities at Vibrent Health! https://cbi.gwu.edu/student-opportunities

Student Opportunities | Computational Biology Institute | The George Washington University ***POSTED 6/21/17***

06/20/2017

Open Postdoctoral Position at NIH in Cancer Genomics https://cbi.gwu.edu/jobs-computational-biology

06/12/2017

Hughes, Nguyen, and Bernot Published in Ecology and Evolution | Computational Biology Institute | The George Washington University

Lily Hughes, Bryan Nguyen, and James Bernot were published in Ecology and Evolution! Great work! https://cbi.gwu.edu/hughes-nguyen-and-bernot-published-ecology-and-evolution

Hughes, Nguyen, and Bernot Published in Ecology and Evolution | Computational Biology Institute | The George Washington University Lily Hughes, Bryan Nguyen, and James Bernot, co-authored an article, "Transcriptomic differentiation underlying marine-to-freshwater transitions in the South American silversides Odontesthes argentinensis and O bonariensis (Atheriniformes)," published in Ecology and Evolution on June 7th, 2017. You…

06/12/2017

Bioinformatician position open at NIH: https://cbi.gwu.edu/node/125/draft

DNA Barcoding analysis of seafood accuracy in Washington, D.C. restaurants 05/01/2017

DNA Barcoding analysis of seafood accuracy in Washington, D.C. restaurants

Professor Keith Crandall and PhD student David Stern co-authored the study, "DNA Barcoding analysis of seafood accuracy in Washington, D.C. restaurants," which was published in PeerJ on April 25th, 2017. In this study, as part of a preliminary legal investigation exploring the viability of a lawsuit under Washington D.C.’s CPPA, the authors sampled the barcoding region of the COI gene to test the identity of commonly mislabeled seafood products from six restaurants in Washington, D.C. They took multiple approaches to identify the sampled specimens. While they reported multiple potentially mislabeled food items, the majority of our tested items were either correctly labeled or were identified as legally acceptable species for the food labeling.

https://peerj.com/articles/3234/

DNA Barcoding analysis of seafood accuracy in Washington, D.C. restaurants In Washington D.C., recent legislation authorizes citizens to test if products are properly represented and, if they are not, to bring a lawsuit for the benefit of the general public. Recent studies revealing the widespread phenomenon of seafood substitution across the United States make it a fertil...

Scientists tested seafood at six D.C. restaurants. It didn’t always match the menu. 04/25/2017

Scientists tested seafood at six D.C. restaurants. It didn’t always match the menu.

CBI DIrector Keith Crandall quoted in the Washington Post!

Scientists tested seafood at six D.C. restaurants. It didn’t always match the menu. The study from George Washington University looked at 12 dishes and found that one-third of the samples were incorrectly labeled.

04/07/2017

www.researchgate.net

Assistant Research Professor Marcos Perez-Losada co-authored the article, "Multilocus sequence typing of pathogens: Methods, analyses, and applications," which was published in Genetics and Evolution of Infectious Diseases in April 2017. The article examines MLST, which was built on the well-established population genetic concepts and methods of the multilocus enzyme electrophoresis (MLEE) technique, but provides significant advantages over this and other typing approaches. MLST has become a standard and flexible approach for characterizing bacteria and some eukaryotes mainly due to the existence of comprehensive databases and its broad implementation in clinical laboratory settings, from basic research laboratories to core sequencing facilities.

https://www.researchgate.net/profile/Eduardo_Castro-Nallar/publication/313426098_Multilocus_Sequence_Typing_of_Pathogens_Methods_Analyses_and_Applications/links/589a1cf54585158bf6f8ab1f/Multilocus-Sequence-Typing-of-Pathogens-Methods-Analyses-and-Applications.pdf

www.researchgate.net

04/04/2017

Assistant Research Professor Marcos Perez-Losada co-authored the study, "Nasopharyngeal microbiome in premature infants and stability during rhinovirus infection," which was published in the Journal of Investigative Medicine on March 31st, 2017. The study considered how the nasopharyngeal (NP) microbiota of newborns and infants plays a key role in modulating airway inflammation and respiratory symptoms during viral infections.

http://jim.bmj.com/content/early/2017/03/31/jim-2017-000414

Computational Biology Institute updated their information in their About section. 03/27/2017

Computational Biology Institute updated their information in their About section.

Computational Biology Institute updated their information in their About section.

Dual Transcriptomic Profiling of Host and Microbiota during Health and Disease in Pediatric Asthma 07/01/2015

Dual Transcriptomic Profiling of Host and Microbiota during Health and Disease in Pediatric Asthma

Read the latest article from CBI members Marcos Perez-Losada, Eduardo Castro-Nallar, Matthew Bendall, and Keith Crandall titled "Dual Transcriptomic Profiling of Host and Microbiota during Health and Disease in Pediatric Asthma".

Dual Transcriptomic Profiling of Host and Microbiota during Health and Disease in Pediatric Asthma Background High-throughput sequencing (HTS) analysis of microbial communities from the respiratory airways has heavily relied on the 16S rRNA gene. Given the intrinsic limitations of this approach, airway microbiome research has focused on assessing bacterial composition during health and disease, a…

Timeline photos 05/18/2015

Congratulations to CBI's first doctoral graduate, Dr. Eduardo Castro-Nallar! Eduardo will continue working with CBI until July when he returns to his native Chile to accept a position in academia.

Faculty Positions in Computational Biology and Bioinformatics 10/03/2014

Faculty Positions in Computational Biology and Bioinformatics

CBI has Faculty Positions in Computational Biology and Bioinformatics open! More information and instructions on how to apply can be found here: https://www.gwu.jobs/postings/24350

Faculty Positions in Computational Biology and Bioinformatics Below you will find the details for the position including any supplementary documentation and questions you should review before applying to the opening. To apply to the position, please click the Apply to this Job link/button.

Postdoctoral Fellow in Metagenomics at George Washington University | Computational Biology... 09/08/2014

Postdoctoral Fellow in Metagenomics at George Washington University | Computational Biology...

CBI is hiring! We are currently looking for a Postdoctoral Fellow in Metagenomics. More information and instructions on how to apply can be found here: https://cbi.gwu.edu/postdoctoral-fellow-metagenomics-george-washington-university

Postdoctoral Fellow in Metagenomics at George Washington University | Computational Biology... Focus on analysis of high-throughput sequencing microbiome data on the role of infectious agents on mental disorders with a focus on schizophrenia.

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